Comments: id = ID, lgcopy=log10(RNA), cd4coun=CD4 count, CD4, CH50, TNF are baseline covariates. id lgcopy day cd4coun ch50 tnf 1 4.36172783601759 2 221.76 NA 32.88 1 3.53147891704225 7 221.76 NA 32.88 1 3.07918124604762 8 221.76 NA 32.88 1 2.97772360528884 16 221.76 NA 32.88 1 2.57978359661681 22 221.76 NA 32.88 1 2.64345267648618 29 221.76 NA 32.88 2 3.3802112417116 2 241.92 NA 25.78 2 1.69897000433601 7 241.92 NA 25.78 3 5.20411998265592 2 101.01 NA NA 3 4.3424226808222 7 101.01 NA NA 3 4.14612803567823 14 101.01 NA NA 4 4.11394335230683 7 17.28 246.33 28.94 4 3.84509804001425 9 17.28 246.33 28.94 4 3.23044892137827 14 17.28 246.33 28.94 4 2.90308998699194 21 17.28 246.33 28.94 4 2.77815125038364 28 17.28 246.33 28.94 5 3.95424250943932 2 155.04 221.6 59.99 5 2.61278385671973 7 155.04 221.6 59.99 5 2.61278385671973 10 155.04 221.6 59.99 5 2.6232492903979 14 155.04 221.6 59.99 5 2.64345267648618 22 155.04 221.6 59.99 5 2.20411998265592 28 155.04 221.6 59.99 6 4.39794000867203 3 182.4 301.3 38.26 6 3.89209460269048 8 182.4 301.3 38.26 6 3.46239799789895 9 182.4 301.3 38.26 6 3.3802112417116 14 182.4 301.3 38.26 6 2.53147891704225 21 182.4 301.3 38.26 6 1.69897000433601 28 182.4 301.3 38.26 7 4.81291335664285 2 263.16 NA 83.09 7 3.74036268949424 6 263.16 NA 83.09 8 5.2552725051033 7 72.8 NA 63.74 8 4.94448267215016 10 72.8 NA 63.74 8 4.27875360095282 14 72.8 NA 63.74 8 4.2552725051033 21 72.8 NA 63.74 8 4.07918124604762 28 72.8 NA 63.74 9 4.88649072517248 2 66.15 NA 35.95 9 3.8750612633917 7 66.15 NA 35.95 9 3.63346845557958 10 66.15 NA 35.95 9 3.49136169383427 14 66.15 NA 35.95 9 3.14612803567823 21 66.15 NA 35.95 9 3.23044892137827 25 66.15 NA 35.95 10 3.81291335664285 7 149.6 279.85 75.72 10 3.94939000664491 9 149.6 279.85 75.72 10 3.2552725051033 14 149.6 279.85 75.72 10 2.81954393554186 21 149.6 279.85 75.72 11 4.43136376415898 7 104.72 302.5 47.42 11 4.30102999566398 9 104.72 302.5 47.42 11 3.88081359228079 14 104.72 302.5 47.42 11 4.04139268515822 20 104.72 302.5 47.42 11 3.56820172406699 28 104.72 302.5 47.42 12 3.53147891704225 7 128.7 200.5 66.24 12 3.11394335230683 9 128.7 200.5 66.24 12 2.53147891704225 14 128.7 200.5 66.24 12 3 20 128.7 200.5 66.24 12 2.17609125905568 28 128.7 200.5 66.24 13 5.93449845124356 2 127.1 270 164.97 13 4.67209785793571 8 127.1 270 164.97 13 4.51851393987788 10 127.1 270 164.97 13 4.14612803567823 15 127.1 270 164.97 13 3.97772360528884 21 127.1 270 164.97 13 3.94939000664491 28 127.1 270 164.97 14 5.23044892137827 2 63.36 188.63 48.17 14 4.32221929473392 6 63.36 188.63 48.17 14 3.83884909073725 9 63.36 188.63 48.17 14 3.23044892137827 14 63.36 188.63 48.17 14 3.14612803567823 21 63.36 188.63 48.17 14 2.86332286012045 28 63.36 188.63 48.17 15 5.5051499783199 2 193.44 218.6 70.24 15 4.82607480270082 8 193.44 218.6 70.24 15 4.56820172406699 10 193.44 218.6 70.24 15 4.04139268515822 21 193.44 218.6 70.24 15 4 28 193.44 218.6 70.24 16 5.27875360095282 2 213.84 168.9 91.75 16 4.2552725051033 7 213.84 168.9 91.75 16 3.66275783168157 10 213.84 168.9 91.75 16 3.47712125471966 21 213.84 168.9 91.75 16 3.36172783601759 28 213.84 168.9 91.75 17 4.5910646070265 2 83.16 191.1 51.71 17 4.41497334797081 6 83.16 191.1 51.71 17 3.86332286012045 9 83.16 191.1 51.71 17 2.79239168949825 13 83.16 191.1 51.71 17 3.23044892137827 21 83.16 191.1 51.71 17 2.47712125471966 29 83.16 191.1 51.71 18 5.51851393987788 2 196.56 241.3 69.99 18 4 6 196.56 241.3 69.99 18 3.54406804435027 9 196.56 241.3 69.99 18 2.53147891704225 13 196.56 241.3 69.99 18 2.71600334363479 21 196.56 241.3 69.99 18 2.66275783168157 29 196.56 241.3 69.99 19 4.39794000867203 2 207.06 175.2 29.99 19 3.76342799356293 6 207.06 175.2 29.99 19 3.66275783168157 9 207.06 175.2 29.99 19 2.98677173426624 14 207.06 175.2 29.99 19 2.73239375982296 21 207.06 175.2 29.99 19 2.71600334363479 29 207.06 175.2 29.99 20 4.54406804435027 2 276 242.1 32.91 20 3.39794000867203 6 276 242.1 32.91 20 2.90308998699194 10 276 242.1 32.91 20 2.90848501887864 13 276 242.1 32.91 20 3.07918124604762 20 276 242.1 32.91 20 2.55630250076728 28 276 242.1 32.91 21 5.98227123303956 2 39.78 253.8 79.96 21 5.07918124604762 6 39.78 253.8 79.96 21 4.20411998265592 9 39.78 253.8 79.96 21 3.72427586960079 13 39.78 253.8 79.96 21 3.3802112417116 20 39.78 253.8 79.96 21 2.98227123303956 28 39.78 253.8 79.96 22 4.8750612633917 3 93 213.2 63.74 22 4.44715803134222 6 93 213.2 63.74 22 3.92427928606188 9 93 213.2 63.74 22 3.36172783601759 13 93 213.2 63.74 22 3.07918124604762 21 93 213.2 63.74 22 3.11394335230683 29 93 213.2 63.74 23 5 2 242 227.8 NA 23 4.79239168949825 6 242 227.8 NA 23 3.68124123737558 9 242 227.8 NA 23 3.5051499783199 13 242 227.8 NA 23 3.14612803567823 21 242 227.8 NA 23 2.99563519459755 28 242 227.8 NA 24 4.8750612633917 2 144.3 243.3 NA 24 3.72427586960079 7 144.3 243.3 NA 25 4.61278385671973 2 387 283.4 68.74 25 3.83884909073725 7 387 283.4 68.74 25 4.04139268515822 9 387 283.4 68.74 25 3.51851393987788 14 387 283.4 68.74 25 3.27875360095282 20 387 283.4 68.74 25 3.11394335230683 28 387 283.4 68.74 26 5.11394335230683 2 108.75 251.8 52.91 26 4.75587485567249 5 108.75 251.8 52.91 26 4 8 108.75 251.8 52.91 26 4.3802112417116 12 108.75 251.8 52.91 26 3.23044892137827 19 108.75 251.8 52.91 26 3.11394335230683 28 108.75 251.8 52.91 27 4.80617997398388 2 216.92 292.1 61.49 27 3.98677173426624 7 216.92 292.1 61.49 27 3.65321251377534 10 216.92 292.1 61.49 27 3.64345267648618 13 216.92 292.1 61.49 28 5.41497334797081 2 257.4 383 153.06 28 4.85125834871907 6 257.4 383 153.06 28 4.39794000867203 9 257.4 383 153.06 28 3.91907809237607 13 257.4 383 153.06 28 4.11394335230683 20 257.4 383 153.06 28 3.46239799789895 28 257.4 383 153.06 29 5.14612803567823 4 NA 202.3 NA 29 5.04139268515822 7 NA 202.3 NA 29 4.07918124604762 11 NA 202.3 NA 29 3.89209460269048 18 NA 202.3 NA 30 4.77085201164214 2 180.81 212.3 NA 30 3.98677173426624 6 180.81 212.3 NA 30 3.43136376415898 10 180.81 212.3 NA 30 3.23044892137827 13 180.81 212.3 NA 30 2.90848501887864 20 180.81 212.3 NA 30 2.49136169383427 28 180.81 212.3 NA 31 4.81291335664285 2 167.28 229.2 52.03 31 4.46239799789895 5 167.28 229.2 52.03 31 4 8 167.28 229.2 52.03 31 3.57978359661681 12 167.28 229.2 52.03 31 3.41497334797081 19 167.28 229.2 52.03 31 3.14612803567823 28 167.28 229.2 52.03 32 5.14612803567823 2 371.91 NA 29.45 32 3.97772360528884 7 371.91 NA 29.45 32 3.83884909073725 9 371.91 NA 29.45 32 3.49136169383427 14 371.91 NA 29.45 32 3.23044892137827 21 371.91 NA 29.45 32 3.07918124604762 28 371.91 NA 29.45 33 4.27875360095282 2 238 300.9 25.78 33 3.3424226808222 7 238 300.9 25.78 33 3.04139268515822 9 238 300.9 25.78 33 3.30102999566398 15 238 300.9 25.78 33 2.85125834871907 21 238 300.9 25.78 33 3.14612803567823 28 238 300.9 25.78 34 6.20411998265592 2 71.4 234.1 49.69 34 5.23044892137827 7 71.4 234.1 49.69 34 4.82607480270082 10 71.4 234.1 49.69 34 4.46239799789895 16 71.4 234.1 49.69 34 3.94448267215016 22 71.4 234.1 49.69 34 3.72427586960079 29 71.4 234.1 49.69 35 4.63346845557958 2 282.24 210.6 58.48 35 4.07918124604762 6 282.24 210.6 58.48 35 3.6232492903979 9 282.24 210.6 58.48 35 3.64345267648618 13 282.24 210.6 58.48 35 3.17609125905568 20 282.24 210.6 58.48 35 2.89762709129044 27 282.24 210.6 58.48 36 5.43136376415898 2 267.52 209.9 41.17 36 4.04139268515822 7 267.52 209.9 41.17 36 3.73239375982296 9 267.52 209.9 41.17 36 3.04139268515822 14 267.52 209.9 41.17 36 3.11394335230683 21 267.52 209.9 41.17 36 2.73239375982296 28 267.52 209.9 41.17 37 6.04139268515822 2 170.66 376 108.19 37 5.23044892137827 7 170.66 376 108.19 37 4.90308998699194 9 170.66 376 108.19 37 4.30102999566398 14 170.66 376 108.19 37 4.41497334797081 21 170.66 376 108.19 37 4.51851393987788 27 170.66 376 108.19 38 4.89762709129044 2 NA 251.7 48.17 38 4.11394335230683 7 NA 251.7 48.17 38 3.64345267648618 10 NA 251.7 48.17 38 2.96848294855393 14 NA 251.7 48.17 38 2.44715803134221 22 NA 251.7 48.17 38 1.69897000433601 29 NA 251.7 48.17 39 5.65321251377534 2 80.64 258.2 56.32 39 4.7481880270062 7 80.64 258.2 56.32 39 4.56820172406699 12 80.64 258.2 56.32 39 3.80617997398388 16 80.64 258.2 56.32 39 3.93951925261861 22 80.64 258.2 56.32 39 3.30102999566398 29 80.64 258.2 56.32 40 4.67209785793571 2 205.35 222.2 61.06 40 3.27875360095282 7 205.35 222.2 61.06 40 2.72427586960078 9 205.35 222.2 61.06 40 2.43136376415898 14 205.35 222.2 61.06 40 2.23044892137827 21 205.35 222.2 61.06 40 2.44715803134221 28 205.35 222.2 61.06 41 5.04139268515822 2 28.5 280.2 61.24 41 4.20411998265592 6 28.5 280.2 61.24 41 3.72427586960079 8 28.5 280.2 61.24 41 3.44715803134222 13 28.5 280.2 61.24 41 3.11394335230683 21 28.5 280.2 61.24 41 2.71600334363479 27 28.5 280.2 61.24 42 4.99563519459755 2 304.92 292.3 57.82 42 3.51851393987788 8 304.92 292.3 57.82 42 3.64345267648618 10 304.92 292.3 57.82 42 3.17609125905568 16 304.92 292.3 57.82 42 2.84509804001425 21 304.92 292.3 57.82 43 5.41497334797081 2 208.08 192.9 49.55 43 4.54406804435027 7 208.08 192.9 49.55 43 3.99563519459755 10 208.08 192.9 49.55 43 3.3424226808222 14 208.08 192.9 49.55 43 3.44715803134222 21 208.08 192.9 49.55 43 3.07918124604762 28 208.08 192.9 49.55 44 5.04139268515822 2 288.8 178.5 81.34 44 3.89762709129044 7 288.8 178.5 81.34 44 3.14612803567823 10 288.8 178.5 81.34 44 3.17609125905568 14 288.8 178.5 81.34 44 3 21 288.8 178.5 81.34 44 3.46239799789895 29 288.8 178.5 81.34 45 5 2 156.4 191.3 44.1 45 4.53147891704225 7 156.4 191.3 44.1 45 4.14612803567823 10 156.4 191.3 44.1 45 3.55630250076728 15 156.4 191.3 44.1 45 2.49136169383427 22 156.4 191.3 44.1 45 3.04139268515822 28 156.4 191.3 44.1 46 4.32221929473392 2 246.24 NA NA 46 3.20411998265592 7 246.24 NA NA 47 5.2552725051033 2 222.3 213.1 39.87 47 5.07918124604762 7 222.3 213.1 39.87 47 4.47712125471966 12 222.3 213.1 39.87 47 4.23044892137827 14 222.3 213.1 39.87 47 3.89762709129044 21 222.3 213.1 39.87 47 3.49136169383427 27 222.3 213.1 39.87 48 4.83250891270623 2 159.12 NA 58.15 48 3.83884909073725 7 159.12 NA 58.15 48 3.17609125905568 10 159.12 NA 58.15 48 2.79239168949825 14 159.12 NA 58.15 48 2.95424250943932 21 159.12 NA 58.15 48 2.6232492903979 28 159.12 NA 58.15