#### Note: id=patient ID, baserna=log10(baseline RNA), for description of
#### other covariates, please see Wu, H. and Wu, L. (2002). "Identification
#### of Significant Host Factors for HIV Dynamics Models by Nonlinear
#### Mixed-Effect Models." Statistics in Medicine, 21, 753-771.

id age baserna wt lu20 apop tnf pcd438 pcd438dr pcd838 pcd838dr ncd438 ncd438dr ncd838 ncd838dr pl4 pl425 pl428 pl8 pl828 nl4 nl425 nl428 nl8 nl828 basech50 bigg bigc3 cd4mem cd8mem cd4na62 cd4nara cd8na62 cd8nara cd4coun cd8coun pk4
1 31 4.36172783601759 136.4 93.238179475072 22.1 32.88 55 13 73 38 122.1 28.86 467.93 243.58 18 11 18 52 26 222 135.52 221.76 641 320.32 NA NA NA 106.4448 275.4752 77.616 42.1344 153.7536 140.9408 221.76 640.64 10819.162
2 41 3.79239168949825 173.8 276.203082359036 15.85 25.78 47 9 57 33 113.74 21.78 350.55 202.95 24 12 16 61 25 242 120.96 161.28 615 252 NA NA NA 116.1216 184.464 70.1568 43.5456 122.976 24.5952 241.92 614.88 1795.683
3 42 5.39794000867203 129.8 287.114127922381 17.75 NA 52 26 79 80 52.52 26.26 447.93 453.6 13 5 9 73 19 101 38.85 69.93 567 147.63 NA NA NA 70.707 300.6213 16.1616 18.1818 107.7699 85.0815 101.01 567.21 NA
4 49 4.77085201164214 165 NA 22.8 28.94 57 37 97 54 9.69 6.29 228.92 127.44 3 2 1 41 12 17 11.6 5.8 236 69.6 246.33 0 7 14.688 125.1648 2.2464 1.5552 35.424 94.464 17.28 236.16 599.224
5 35 3.92941892571429 136 NA 24.1 59.99 76 26 76 57 117.8 40.3 942.4 706.8 8 2 8 64 15 155 38.8 155.2 1240 291 221.6 7 52 103.8768 781.4016 44.9616 41.8608 136.4352 372.096 155.04 1240.32 3599.583
6 47 5.41497334797081 170 NA 12.8 38.26 6 2 5 31 10.92 3.64 30.2 187.24 16 4 9 53 13 182 44.8 100.8 604 145.6 301.3 6 39 136.8 404.814 12.768 25.536 18.126 102.714 182.4 604.2 14200.231
7 48 4.5051499783199 158 494.51 11 83.09 63 23 74 38 165.69 60.49 660.08 338.96 18 4 11 61 8 263 58.4 160.6 892 116.8 NA NA NA 205.2648 383.4826 7.8948 21.0528 62.4274 383.4826 263.16 891.82 NA
8 35 5.17609125905568 166 NA 25.95 63.74 16 10 10 49 11.68 7.3 36.4 178.36 7 2 6 35 18 73 20.8 62.4 364 187.2 NA NA NA 0 7.28 2.184 0 3.64 0 72.8 364 4757.216
9 32 4.93951925261861 170 NA 24.4 35.95 72 20 66 23 47.52 13.2 445.5 155.25 5 1 3 51 14 66 13.3 39.9 675 186.2 NA NA NA 39.69 391.3434 25.137 16.5375 80.9676 222.6609 66.15 674.73 2575.681
10 43 4.82607480270082 163 NA 10.75 75.72 55 15 53 38 82.5 22.5 222.07 159.22 10 1 6 28 8 150 15.2 91.2 419 121.6 279.85 7 52 88.264 217.8176 50.864 46.376 58.6432 159.1744 149.6 418.88 4347.189
11 30 5.32221929473392 218 NA 32.2 47.42 14 3 16 9 14.7 3.15 28.8 16.2 14 0 2 24 7 105 0 15.2 180 53.2 302.5 4 57 47.124 75.3984 6.2832 3.1416 8.976 25.1328 104.72 179.52 1711.503
12 46 4.14612803567823 224 NA 27.85 66.24 55 21 76 38 70.95 27.09 533.52 266.76 11 3 9 60 22 129 35.1 105.3 702 257.4 200.5 7 52 33.462 491.4 32.175 21.879 119.34 70.2 128.7 702 3706.671
13 33 5.78532983501076 167 NA 19.3 164.97 77 18 97 52 97.79 22.86 788.61 422.76 10 4 8 64 8 127 50.4 100.8 813 100.8 270 3 34 72.447 349.7792 44.485 36.859 32.5376 219.6288 127.1 813.44 6291.22
14 37 5.53147891704225 140 NA 11.3 48.17 72 36 74 59 45.36 22.68 476.56 379.96 6 2 5 61 18 63 20.4 51 644 183.6 188.63 5 48 45.6192 219.0144 5.7024 3.8016 64.416 173.9232 63.36 644.16 29725.627
15 28 5.50515 165 NA 12.05 70.24 75 16 80 46 144.75 30.88 600 345 16 4 12 62 14 193 48.4 145.2 750 169.4 218.6 5 47 90.9168 299.832 83.1792 87.048 322.3194 404.7732 193.44 749.58 21767.926
16 40 5.2552725051033 164 24.09 17.7 91.75 56 30 56 42 119.84 64.2 379.12 284.34 18 5 15 57 22 214 58 174 677 255.2 168.9 3 50 143.2728 291.1788 38.4912 57.7368 60.9444 264.0924 213.84 677.16 NA
17 44 4.75587485567249 114 NA 28.4 51.71 78 38 84 68 64.74 31.54 263.76 213.52 18 8 15 68 23 83 36.96 69.3 314 106.26 191.1 3 54 69.8544 273.3192 14.9688 4.9896 28.2744 0 83.16 314.16 35150.101
18 32 4.93449845124356 159 NA 28.8 69.99 79 39 74 67 155.63 76.83 469.9 425.45 13 2 9 42 23 197 30.24 136.08 635 347.76 241.3 4 55 145.4544 450.8784 41.2776 35.3808 107.9568 114.3072 196.56 635.04 7953.21
19 56 4.30102999566398 150 NA 24 29.99 60 25 68 56 124.2 51.75 348.84 287.28 21 6 18 52 23 207 59.16 177.48 513 226.78 175.2 3 57 163.5774 317.8864 33.1296 28.9884 66.6536 112.7984 207.06 512.72 13503.651
20 43 4.04139268515822 166 2736.80197670937 20.3 32.91 39 12 51 34 107.64 33.12 379.44 252.96 23 10 20 62 22 276 120 240 744 264 242.1 2 47 223.56 372 55.2 38.64 81.84 245.52 276 744 0
21 40 5.44715803134222 195 650.971105389256 6 79.96 73 31 92 73 29.2 12.4 347.76 275.94 6 4 5 57 12 40 26.52 33.15 378 79.56 253.8 12 48 24.6636 177.6177 16.3098 0.3978 18.8955 64.2447 39.78 377.91 7042.014
22 43 5.11394335230683 124 NA 18.6 63.74 78 45 79 65 72.54 41.85 374.46 308.1 10 3 7 51 16 93 27.9 65.1 474 148.8 213.2 2 52 68.82 388.926 13.02 20.46 28.458 61.659 93 474.3 13629.339
23 31 5.47712125471966 158 3704.15 21.6 NA 64 21 65 47 154.88 50.82 986.7 713.46 11 3 8 69 21 242 66 176 1518 462 227.8 4 52 169.4 1062.6 53.24 41.14 30.36 258.06 242 1518 19784.872
24 29 4.92941892571429 154 1264.4929316208 5.5 NA 73 17 78 50 105.12 24.48 563.16 361 13 3 12 65 33 144 33.3 133.2 722 366.3 243.3 4 54 73.593 317.46 69.264 15.873 86.58 7.215 144.3 721.5 0
25 63 4.83884909073725 192 10344.88834983 16.4 68.74 46 23 70 47 178.02 89.01 888.3 596.43 18 2 8 59 15 387 43 172 1269 322.5 283.4 8 70 301.86 558.14 34.83 23.22 126.85 532.77 387 1268.5 2085.969
26 35 5.20411998265592 165 599.419826571943 20.3 52.91 89 21 96 83 97.01 22.89 452.16 390.93 15 3 13 65 22 109 21.75 94.25 471 159.5 251.8 0 2 41.325 348.725 63.075 41.325 51.8375 47.125 108.75 471.25 14191.116
27 55 4.55630250076728 145 223.887931768572 3.7 61.49 69 34 86 80 149.73 73.78 658.76 612.8 17 4 15 60 25 217 51.04 191.4 766 319 292.1 4 73 164.8592 535.92 39.0456 26.0304 30.624 107.184 216.92 765.6 11457.85
28 64 5.11394335230683 198 68.3047871150126 3.1 153.06 83 58 83 57 213.31 149.06 1215.95 835.05 13 3 8 74 11 257 59.4 158.4 1465 217.8 383 4 61 95.238 761.904 36.036 0 58.608 0 257.4 1465.2 6072.192
29 35 5.20412 143 89.0138 22.2 NA 62 26 67 28 NA NA NA 233.24 7 2 6 75 21 78 20.48 61.44 833 215.04 202.3 1 55 NA NA NA NA NA NA NA NA 0
30 37 4.32221929473392 170 735.893469331415 34 NA 56 40 73 42 101.36 72.4 1026.38 590.52 9 4 6 70 21 181 80.36 120.54 1406 421.89 212.3 6 61 141.0318 590.646 19.8891 21.6972 70.315 506.268 180.81 1406.3 9102.101
31 36 4.83884909073725 190 317.769756643689 20.3 52.03 80 36 76 49 133.6 60.12 784.32 505.68 12 4 10 74 13 167 55.76 139.4 1032 181.22 229.2 6 43 108.732 515.78 45.1656 35.1288 103.156 237.2588 167.28 1031.56 3653.932
32 34 5.04139268515822 137 46.36 14 29.45 64 37 95 65 238.08 137.64 2441.5 1670.5 11 4 9 76 24 372 135.24 304.29 2570 811.44 NA NA NA 308.6853 1721.6052 37.191 33.4719 179.8692 488.2164 371.91 2569.56 NA
33 42 4.30102999566398 178.2 108.440068777047 22.75 25.78 72 14 60 33 171.36 33.32 386.4 212.52 17 9 14 46 29 238 126 196 644 406 300.9 1 43 66.64 128.8 121.38 78.54 218.96 83.72 238 644 2957.591
34 43 5.90848501887865 154 1118.42392434086 60.85 49.69 88 53 98 82 62.48 37.63 398.86 333.74 10 8 10 57 17 71 57.12 71.4 407 121.38 234.1 7 54 34.272 85.4658 14.28 7.854 101.745 122.094 71.4 406.98 4018.22
35 45 4.83884909073725 154 145.3996672452 34.5 58.48 66 36 83 65 186.12 101.52 1070.7 838.5 14 3 6 64 13 282 68.04 136.08 1290 294.84 210.6 5 43 118.5408 387.072 73.3824 22.5792 399.9744 38.7072 282.24 1290.24 5226.422
36 43 5.3802112417116 147.4 149.203924964771 21.05 41.17 70 40 81 75 187.6 107.2 532.17 492.75 22 10 17 54 17 268 106.4 180.88 657 180.88 209.9 8 50 69.5552 32.832 74.9056 74.9056 144.4608 144.4608 267.52 656.64 2204.241
37 56 6.07918124604762 176 45.461268441555 22.2 108.19 84 33 97 86 143.64 56.43 431.65 382.7 23 11 16 60 9 171 81.62 118.72 445 66.78 376 6 45 58.0244 71.232 85.33 47.7848 66.78 102.396 170.66 445.2 3844.41
38 36 5.27875360095282 147.4 226.54 44.7 48.17 74 22 97 73 97.68 29.04 1728.54 1247.4 NA 3 5 81 8 132 73.92 123.2 1782 197.12 251.7 31 48 NA NA NA NA NA NA NA NA 31713.967
39 33 5.5051499783199 151.8 76.8132536399668 9 56.32 88 23 97 82 71.28 18.63 273.54 231.24 18 9 14 63 12 81 40.32 62.72 282 53.76 258.2 8 50 20.9664 79.0272 33.8688 23.3856 25.4016 47.9808 80.64 282.24 NA
40 55 4.07918124604762 167.2 552.531841983568 10.75 61.06 62 34 75 32 127.1 69.7 657 280.32 15 6 12 64 24 205 79.92 159.84 876 319.68 222.2 11 55 82.14 262.848 57.498 20.535 70.0928 17.5232 205.35 876.16 11075.473
41 33 5.75587485567249 147.4 143.325545226842 20.4 61.24 84 66 90 73 24.36 19.14 349.2 283.24 5 2 3 68 20 29 11.4 17.1 388 114 280.2 11 59 12.255 85.272 1.14 2.85 58.14 139.536 28.5 387.6 200.896
42 23 5.17609125905568 178.2 79.6850644741761 43.25 57.82 68 26 94 78 207.4 79.3 941.88 781.56 21 9 18 69 18 305 130.68 261.36 1002 261.36 292.3 10 43 97.5744 350.658 100.6236 51.8364 90.1692 80.1504 304.92 1001.88 1035.669
43 33 5.43136376415898 173.8 345.26939359776 30 49.55 74 44 80 57 153.92 91.52 956.8 681.72 12 3 6 69 17 208 52.02 104.04 1196 294.78 192.9 NA NA 83.232 370.9026 54.1008 20.808 107.6814 11.9646 208.08 1196.46 3120.65
44 32 4.98227123303956 167 655.814724422996 33.1 81.34 66 32 81 75 205.92 99.84 664.2 615 19 12 11 50 11 312 186.96 171.38 820 171.38 178.5 5 48 127.072 167.2 103.968 37.544 167.2 121.6 288.8 760 5362.03
45 39 4.85125834871907 250.8 93.6065623202121 22.8 44.1 62 10 77 38 96.72 15.6 311.85 153.9 17 9 13 44 22 156 89.64 129.48 405 219.12 191.3 1 4 46.92 129.536 82.892 34.408 174.064 141.68 156.4 404.8 4797.048
46 38 4.07918124604762 167.2 56.855421940685 34.8 NA 86 50 92 80 211.56 123 877.68 763.2 16 10 10 62 19 246 153.9 153.9 954 292.41 NA NA NA 61.56 162.2106 73.872 51.7104 238.545 219.4614 246.24 954.18 NA
47 47 5.27875360095282 169.4 240.782308823878 23.4 39.87 72 16 92 15 159.84 35.52 1035.92 168.9 15 8 8 76 10 222 118.56 118.56 1126 148.2 213.1 7 54 100.035 202.7376 35.568 17.784 168.948 135.1584 222.3 1126.32 4776.51
48 24 4.74036268949424 112.2 130.429225029592 53.5 58.15 79 8 87 38 125.61 12.72 431.52 188.48 17 3 14 53 14 159 28.08 131.04 496 131.04 NA NA NA 58.8744 372.06 79.56 52.5096 54.5688 94.2552 159.12 496.08 NA