Hulin Wu Lab

Biographical Sketch

Education

  • Ph.D., Statistics, 1994, Department of Statistics, Florida State University, Tallahassee, Florida USA
  • M.S., Statistics, 1991, Department of Statistics, Florida State University, Tallahassee, Florida USA
  • M.S., Engineering, 1987, Department of Automatic Control, National University of Defense Technology, P.R. China
  • B.S., Engineering, 1984, Department of Automatic Control, National University of Defense Technology, P.R. China

Positions and Appointments

  • 2017-present The Betty Wheless Trotter Professor & Chair, Department of Biostatistics & Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX.

  • 2015-present Professor, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX.

  • 2015-2017     Dr. D.R. Seth Family Professor and Associate Chair, Department of Biostatistics, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX.

  • 2012-2015. Founding Director, Center for Integrative Bioinformatics and Experimental Mathematics, University of Rochester School of Medicine and Dentistry, Rochester, NY
  • 2011-2015. Appointed as Dean’s Professor in recognition of my contribution in helping to shape the life of the institution in a significant way, University of Rochester School of Medicine and Dentistry, Rochester, NY
  • 2006-2011, Co-Director, Biomedical Informatics Program, Clinical and Translational Science Institute (CTSI), University of Rochester Medical Center, Rochester, NY
  • 2005-2015, Director, Center for Biodefense Immune Modeling, University of Rochester Medical Center, Rochester, NY
  • 2004-2012, Founding Chief, Division of Biomedical Modeling and Informatics, Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY
  • 2004-2015, Professor, Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
  • 2004-2015, Professor, Department of Community and Preventative Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
  • 2003-2015, Professor, Department of Biostatistics and Computational Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA
  • 2000-2003, Adjunct Lecturer, Department of Biostatistics, Harvard University, Boston MA, USA
  • 2002-2003,Principal Research Scientist, Frontier Science & Technology Research Foundation (non-profit), Chestnut Hill, MA, USA
  • 1996-2002, Senior Statistical Scientist, Frontier Science & Technology Research Foundation (non-profit), Chestnut Hill, MA, USA
  • 1996-2002, Head, Pharmacology/Dynamic Modeling Section, SDAC/AACTG, Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA
  • 1994-1996, Visiting Assistant Professor, Department of Mathematical Sciences, University of Memphis, Memphis, TN, USA
  • 1989-1994, Teaching Assistant, Department of Statistics, Florida State University, Tallahassee, FL, USA
  • 1987-1989, Engineer, Academy of Launch Vehicle Technology, Beijing , P.R. China

Awards and Honors

  • Best First-Year Student Award (1990), Department of Statistics, Florida State University
  • First Prize, Student Paper Awards, the 1993 Joint Statistical Meetings, San Francisco, Section on Statistics and the environment, American Statistical Association
  • The ENAR Student Paper Award, the 1994 Spring Meetings, Cleveland, Ohio, the Eastern North American Region of the Biometrics Society (ENAR)
  • Ralph A. Bradley Award (for the most outstanding Ph.D graduate), 1994, Department of Statistics, Florida State University (FSU)
  • The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association
  • Young Scientist Scholarship Fund Award, 1997, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, St. Petersburg, Florida
  • The First Independent Research Support & Transition (FIRST) Awards, 1998-2003, National Institutes of Health (NIH)
  • Young Scientist Scholarship Fund Award, 1998, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies, Lake Maggiore, Italy
  • Grant proposal review for Developmental Grants Program, Center for AIDS Research (CFAR), University of Washington, 2000
  • Grant proposal review for Dutch AIDS Fund, Amsterdam, Netherlands, 2001
  • Biocomputational Panel of the Information Technology Research Program, the National Science Foundation (NSF), 2003
  • Center Grant Reviewer, National Institute on Drug Abuse, National Institutes of Health (NIH), 2005
  • Grant proposal review for the section of Drug Discovery and Mechanisms of Antimicrobial Resistance, National Institutes of Health (NIH), 2005
  • Fellow, American Statistical Association, 2008
  • The Scientific Advisory Board member, the BMGF-funded (Gate's Foundation) Vaccine Immunology Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, 2009

Research Interests

  • Big Health Care Data: EHR and insurance claims data.
  • Biomedical Big Data Analytics: Complex high-dimensional data from high-throughput technologies.
  • Statistical Methods and Theories for Differential Equation Models.
  • Computational Systems Biology and Bioinformatics: Genetic and protein network and multi-scale modeling.
  • Immunological Data Analysis and Modeling: Modeling immune response to influenza and HIV infection.
  • Biomathematical Modeling: Clinical trial modeling and simulations, modeling HIV RNA/cellular dynamics, dynamic prediction of antiviral responses, and modeling AIDS epidemics.
  • Clinical Trials: Clinical trial design, pharmacokinetics and pharmacodynamics (PK/PD) study and Phase I trial design and modeling.
  • Longitudinal Data: Nonparametric regression methods and mixed-effects models.
  • Other Statistical Methodologies: High-dimensional variable selection, Markov chain Monte Carlo (MCMC), Bayesian methods, state-space models, measurement error models, missing data, and spatial statistics.

Teaching Experience

09/2015-present. As Professor at University of Texas School of Public Health, courses developed and taught:

  • Data Science Analytics Methods (I)
  • Categorical Data Analysis

08/2003–2015.  As Full Professor at the University of Rochester, courses taught and developed:

  • Linear Models, Seminar in Statistical Literature, Topics in Biostatistics: Monte Carlo Methods and Modeling of Biomedical Dynamic Systems, Statistical Inference for M.S. and Ph.D. graduate students.

  08/1994–07/1996.  As Assistant Professor at the University of Memphis, courses taught:

  • Introduction to Probability Theory and Applied Probability and Queueing Theory, for undergraduate and non-statistics major students.
  • Multivariate Statistical Methods, Experimental Design and Inference Theory, for M.S. and Ph.D. graduate students in statistics.

09/1989–08/1994. As Teaching Assistant at the Florida State University, assisted in teaching    following statistical courses:

  • Fundamental Business Statistics, Statistics through Example, Analysis of Variance and Design of Experiments, Mathematical Statistics, Introductory Probability, Time Series  and Forecasting Methods.  

RegNetwork

RegNetwork is a data repository of five-type transcriptional and post-transcriptional regulatory relationships for human and mouse .

IMC Portal

IMC Portal features news and resources relevant to investigators interested in immune response modeling for infectious disease research.

Bio-Lab Informatics Server (BLIS)

A Web-Based Data Management System for Immunologic Research.

DEDiscover

Differential equations modeling, simulation, and parameter estimation

D-NetWeaver

D-NetWeaver is an application to enable the manipulation and analysis of time course data matrices, such as gene expression data as generated by microarray or RNA-seq experiments.

HIV Viral Fitness Calculator

Competitive Virus Fitness: Calculations & Estimation of Viral Fitness

Matlab Codes for Non-parametric Regression Methods for Longitudinal Data Analysis: MIxed-Effects Modeling Approaches

Books

Wai-Yuan Tan and Hulin Wu (2005), Deterministic and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention, World Scientific, Singapore.

Hulin Wu and Jin-Ting Zhang (2006), Nonparametric Regression Methods for Longitudinal Data Analysis: Mixed-Effects Modeling Approaches, John Wiley & Sons, Inc., New York.

Peer-Reviewed Journals

2018

  • Saha, J.M., Liu, H., Hu, P.W., Nikolai, B.C., Wu, H., Miao, H., Rice, A.P. (2018), Proteomic profiling of a primary CD4+ T cell model of HIV-1 latency identifies proteins whose differential expression correlates with reactivation of latent HIV-1, AIDS Research and Human Retroviruses, 34(1):103-110.
  •  Carey, M.+,  Ramfrez, J.C.+, Wu, S., Wu, H.* (2018), A Big Data Pipeline: Identifying Dynamic Gene Regulatory Networks from Time Course GEO Data with Applications toInfluenza Infection, Statistical Methods in Medical Research, in press. https://doi.org/10.1177%2F0962280217746719
  •  Song, J., Carey, M.+, Zhu, H., Miao, H., Ramfrez, J.C.+, and Wu, H.* (2018), Identifying the dynamic gene regulatory network during latent HIV-1 reactivation using high-dimensional ordinary differential equations, International Journal of Computational Biology and Drug Design (IJCBDD), in press.
  • Xue, H., Wu, S., Wu, Y., Wu, H.* (2018), Independence Screening for High Dimensional Nonlinear Additive ODE Models with Applications to Dynamic Gene Regulatory Networks, Statistics in Medicine, in press. https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.7669
  • Wu, L.+, Qiu, X., Yuan, Y.X., Wu, H.* (2018), Parameter Estimation and Variable Selection for Big Systems of Linear Ordinary Differential Equations: A Matrix-Based Approach, Journal of the American Statistical Association, in press. https://doi.org/10.1080/01621459.2017.1423074
  •  Xue, H., Kumar, A., Wu, H.* (2018), Parameter Estimation for Semiparametric Ordinary Differential Equation Models, Communications in Statistics-Theory and Methods, accepted.
  • Chen, G., Ramírez, J.C., Deng, N., Qiu, X., Wu, C., Zheng, W.J., and Wu, H.* (2018), Restructured GEO: Restructuring Gene Expression Omnibus metadata for genome dynamics analysis, DATABASE-The Journal of Biological Databases and Curation, conditionally accepted.

2017

  • Chen, I., Kelkar, Y., Gu, Y., Zhou. J., Qiu, X., Wu, H.* (2017), High-Dimensional Linear State Space Models for Dynamic Microbial Interaction Networks, PLOS ONE, 12(11): e0187822. https://doi.org/10.1371/journal.pone.0187822.

2016

  • Lu, N.+, Silva, J., Gu, Y., Wu, H., Gelbard, H., Dewhurst, S., Miao, H. (2016), Capillary Extraction by Detecting Polarity in Circular Profiles”, IET Image Processing, 10(5): 339-348.
  • Shen, S. S.,Li, J. J., Hilchey, S. S., Shen, X. X., Tu, C. C., Qiu, X. X., Ng, A. A., Ghaemmaghami, S. S., Wu, H., Zand, M. S., Qu, J. J.* (2016), Ion-Current-Based Temporal Proteomic Profiling of Influenza-A-Virus-Infected Mouse Lungs Revealed Underlying Mechanisms of Altered Integrity of the Lung Microvascular Barrier.  Journal of Proteome Research. 15(2), 540-553. http://dx.doi.org/10.1021/acs.jproteome.5b00927.
  • Yang, H., Baker, S.F., Gonzalez, M.E., Topham, D.J., Martinez-Sobrido, L., Zand, M., Holden-Wiltse, J., Wu, H. (2016), An Improved Method for Estimating Antibody Titers in Microneutralization Assay Using Green Fluorescent Protein, Journal of Biopharmaceutical Statistics, 26(3): 409-420. doi: 10.1080/10543406.2015.1052475.
  • Carey, M.+, Wu, S., Gan, G., Wu, H.* (2016), Correlation-based iterative clustering methods for time course data: the identification of temporal gene response modules for influenza infection in humans, Infectious Disease Modelling, 1(1), 28-39.
  • Sun, X.+, Hu, F.+, Wu, S., Qiu, X., Linel, P.+, Wu, H.* (2016), Controllability and Stability Analysis of Large Transcriptomic Dynamic Systems for Host Response to Influenza Infection in Human, Infectious Disease Modelling, 1(1), 52-70.

2015

  • Qiu, X., Wu, S., Wu, H. (2015), A New Information Criterion Based on Mixture Langevin Distribution for Clustering Circular Data with Application to Time-course Genomic Data, Statistica Sinica, 25, 1459-1476.
  • Wu, H.*, Miao, H., Xue, H., Topham, D.J., Zand, M. (2015), Quantifying Immune Response to Influenza Virus Infection via Multivariate Nonlinear ODE Models with Partially Observed State Variables and Time-Varying Parameters, Statistics in Biosciences, 7(1):147-166.
  • Liu, Z.P.+, Wu, C., Miao, H., Wu, H.* (2015), RegNetwork: an Integrated Database of Transcriptional and Posttranscriptional Regulatory Networks in Human and Mouse, DATABASE-The Journal of Biological Databases and Curation, 2015: article ID bav095; doi:10.1093/ database/bav095.
  • Qiu, X., Wu, S., Hilchey, S.P., Thakar, J., Liu, Z.P., Welle, S.L., Henn, A.D., Wu, H.*, Zand, M.S.* (2015), Diversity in Compartmental Dynamics of Gene Regulatory Networks: The Immune Response in Primary Influenza A Infection in Mice, PLoS ONE, 10(9): e0138110. DOI: 10.1371/journal.pone.0138110.

2014

  • Gu, W., Wu. H., Miao, H., and Xue, H. (2014), Parameter Estimation for a Type of Nonlinear Stochastic Models Observed with Error, Computational Statistics and Data Analysis, 79, 113-119. Paper | Matlab code & Data
  • Miao, H., Sangster, M.Y., Livingstone, A.M., Hilchey, S., Zhang, L., Topham, D.J., Mosmann, T.R., Holden-Wiltse, J., Perelson, A.S., Wu, H.*, Zand, M.S.* (2014), Modeling the Dynamics and Migratory Pathways of Virus-Specific Antibody-Secreting Cell Populations in Primary Influenza Infection, PLoS ONE, 9(8):e104781. PMID:25171166 | C code & Data
  • Miao, H., Wu, H., and Xue, H. (2014), Generalized Ordinary Differential Equation Models, Journal of the American Statistical Association, 2014 Oct;109(508):1672-1682. PMID:25544787 | C code & Data
  • Wu, S., Liu, Z.P., Qiu, X., and Wu, H.* (2014), Modeling genome-wide dynamic regulatory network in mouse lungs with influenza infection using high-dimensional ordinary differential equations, PLOS ONE, 2014 May 6;9(5):e95276. PMID:24802016R Code | Data
  • Wu, H.*, Lu, T., Xue, H., and Liang, H. (2014), Sparse Additive ODEs for Dynamic Gene Regulatory Network Modeling, Journal of the American Statistical Association, 2014 Apr 2;109(506):700-716. PMID:2378633 | Data | R Code | GUI Tool
  • Wu, S., Xue, H., Wu, Y., Wu, H. (2014), Variable Selection for Sparse High-Dimensional Nonlinear Regression Models by Combining Nonnegative Garrote and Sure Independence Screening, Statistica Sinica, 2014 Jul;24(3):1365-1387. PMID:25170239 | Data | Matlab Code
  • Ding, A.A. and Wu, H.* (2014), Estimation of ODE Parameters Using Constrained Local Polynomial Regression, Statistica Sinica, 24, 1613-1631. PaperR codeData
  • Linel, P., Wu, S., Deng, N., Wu, H.* (2014), Dynamic transcriptional signatures and network responses for clinical symptoms in influenza-infected human subjects using systems biology approaches, Journal of Pharmacokinetics and Pharmacodynamics, 41, 509-521, PMID:25015847.
  • Amneris E. Luque, Mark Orlando, U-Cheng Leong, Paul D. Allen, Joseph J. Guido, Hongmei Yang and Hulin Wu (2014), Hearing Function in Patients Living with HIV/AIDS, Ear and Hearing, 2014 Nov-Dec;35(6):e282-90. PMID:25127320
  • Liu, Z., Wu, H., Zhu, J., Miao, H. (2014), Systematic Identification of Transcriptional and Post-Transcriptional Regulatory Relationships during Influenza Virus Infection, BMC Bioinformatics,15(1): 336. PMID:25281301 | R code & Data

2013

  • Wang, J., Zhang, L., Jing, C., Ye, G., Wu, H., Miao, H., Wu, Y., Zhou X. (2013), Multi-scale agent-based modelling on melanoma and its related angiogenesis analysis, Theoretical Biology and Medical Modelling, 10:41
  • Yang, H., Topham, D., Holden-Wiltse, J., Wu, H. (2013), Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays , Journal of Biopharmaceutical Statistics,23, 921-926. PMID: 23786336 | R Code
  • Wu, S, and Wu, H.* (2013), More Powerful Significant Testing for Time Course Gene Expression Data Using Functional Principal Component Analysis Approaches, BMC Bioinformatics, 14:6. PMID: 23323795 | R Code | Data | GUI Tool
  • Lu, N., Silva, J., Gu, Y., Gerber, S., Wu, H., Gelbard. H., Dewhurst, S., Miao, H. (2013), Directional histogram ratio at random probes: A local thresholding criterion for capillary images, Pattern Recognition, 46(7), 1933-1948. PMID: 23525856 | Matlab Code
  • Qiu, X., Wu, H. and Hu, R. (2013), The Impact of Quantile and Rank Normalization Procedures on the Testing Power of Gene Differential Expression Analysis, BMC Bioinformatics,14:124. PMID: 23578321
  • Luo, R., Piovoso, M.J., Wu, H., Buzon, M.J., Martinez-Picado, J., Zurakowski, R. (2013), Modeling HIV-1 2-LTR Dynamics Following Raltegravir Intensification, Journal of the Royal Society Interface, 10:20130186. PMID: 23658114
  • Yanni Xiao, Hongyu Miao, Sanyi Tang, Hulin Wu* (2013), Modeling Antiretroviral Drug Responses for HIV-1 infected Patients Using Differential Equation Models, Advanced Drug Delivery Reviews, 65, 940-953. PMID: 23603208
  • Alicia D. Henn, Shuang Wu, Xing Qiu, Melissa Ruda, Michael Stover, Hongmei Yang, Zhiping Liu, Stephen Welle, Jeanne Holden-Wiltse, Hulin Wu*, Martin S. Zand* (2013), High-Resolution Temporal Response Patterns to Influenza Vaccine Reveal a Distinct Human Plasma Cell Gene Signature, Nature Scientific Reports, 3:2327. PMID: 23900141 | Data
  • Jason M Weaver; Hongmei Yang; David Roumanes; Frances Eun-Hyung Lee; Hulin Wu; John J. Treanor; Tim R Mosmann (2013), Increase in IFNγ(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza, PLoS One, 8(3):e57275. PMID: 23526940

2012

  • Wu, H.*, Xue, H., Kumar A. (2012), Numerical Discretization-Based Estimation Methods for Ordinary Differential Equation Models via Penalized Spline Smoothing with Applications in Biomedical Research., Biometrics, 68(2):344-52 .PMID:22376200 | | Technical Proof | R Code Patient 1 Data | Patient 2 Data
  • Cao, J., Huang, J.Z., Wu, H. (2012), Penalized Nonlinear Least Squares Estimation of Time-Varying Parameters in Ordinary Differential Equations, Journal of Computational and Graphical Statistics (JCGS), 21:1, 42-56.PMID: 23155351
  • Lee, Y. and Wu, H.* (2012), MARS Approach for Global Sensitivity Analysis of Differential Equation Models with Applications to Dynamics of Influenza Infection, Bulletin of Mathematical Biology, 74(1):73-90.PMID: 21656089
  • Miao, H., Jin, X., Perelson, A.S., Wu, H. (2012), Evaluation of Multitype Mathematical Models for CFSE-Labeling Experiment Data, Bulletin of Mathematical Biology, 74(2):300-26. PMID: 21681605 | Data | C Code
  • Zhou, J., Liu, S.Y., Zhou, F., Wu, H. (2012), Statistical Diagnosis of HIV Model (in Chinese). Chin Sci Bull (Chin Ver). 2012, 57: 666–672, doi: 10.1360/972011-1978.Paper
  • Henn, A.D., Laski, M., Yang, H., Qiu, X., Miao, H., Barry, C.T., Welle, S., Wu, H., Zand, M.S. (2012), Functionally Distinct Subpopulations of CpG-Activated Memory B Cells, Nature Scientific Reports, 2012;2:345. PMID: 22468229 | Data
  • Li, X., Miao, H., Henn, A.D., Topham, D.J.,  Wu, H.,  Zand, M.S., and Mosmann, T.R. (2012), Ki-67 Expression Reveals Strong, Transient Influenza Specific CD4 T Cell Responses After Adult Vaccination, Vaccine, 30, 4581-4584. .PMID: 22554464
  • Tang, S., Xiao, Y., Wang, N., and Wu, H. (2012), Piecewise HIV virus dynamic model with CD4+ T cell count-guided therapy: I, Journal of Theoretical Biology, 308, 123-234. PMID: 22659043

2011

  • Wang, J., Zhang, G.,  Bambara, R.,  Li, D., Liang, H.,  Wu, H.,  Smith, H.,  Lowe, N.,  Demeter, L., and Dykes, C. (2011), Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI)-resistant Virus is Stimulated by Efavirenz (EFV) During Early Stages of Infection, Journal of Virology, 85(20):10861-73. PMID:21835788
  • Wu, H., Kumar, A., Miao, H., Holden-Wiltse, J., Mosmann, T.R., Livingstone, A.M., Belz, G.T., Perelson, A.S., Zand, M., Topham, D.J. (2011), Modeling of Influenza-Specific CD8+ T Cells During the Primary Response Indicates that the Spleen Is a Major Source of Effectors, Journal of Immunology, 187, 4474-4482. PMID:21948988 | Data1 | Data2 | GUI Tool
  • Lu, T., Liang, H., Li, H., Wu, H. (2011), High Dimensional ODEs Coupled with Mixed-Effects Modeling Techniques for Dynamic Gene Regulatory Network Identification, Journal of the American Statistical Association, JASA, 106:496 1242-1258. PMID: 21681605AppendixR Code | GUI Tool
  • Liu, D., Lu, T., Niu, X.F., and Wu, H.* (2011), Mixed-Effects State Space Models for Analysis of Longitudinal Dynamic Systems, Biometrics, 67, 476-485.PMID:20825393
  • Fang, Y., Wu, H., Zhu, L. (2011), A Two-Stage Estimation Method for Random Coefficient Differential Equation Models with Application to Longitudinal HIV Dynamic Data, Statistica Sinica, 21, 1145-1170. PMID:22171150
  • Miao, H., Xia, X., Perelson, A.S., Wu, H. (2011), On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics, SIAM Review, 53, 3-39.PMID:21785515
  • Huang, Y., Wu, H., Holden-Wiltse, J., Acosta, P. (2011), A Dynamic Bayesian Nonlinear Mixed-Effects Model of HIV Response Incorporating Medication Adherence, Drug Resistance and Covariates, The Annals of Applied Statistics, 5(1), 551-577,.PMID: 22171150
  • Lartey, M., Sagoe, K.W., Yang, H., Kenu, E., Xexemeku, F., Oliver-Commey, J., Bioma, V., Seshie, M., Sagoe, A., Mingle, J., Flanigan, T.P., Wu, H., Kwara, A. (2011), Viral Decay Rates Are Similar in HIV-Infected Patients with and without TB Coinfection Treated with Efavirenz-containing Antiretroviral Therapy, Clinical Infectious Diseases, 52(4), 547-550. PMID:21252140

2010

  • Zhang, J.T., Wu, H. (2010), Modeling HIV Dynamics Using Unified Mixed-effects Models, American Journal of Mathematical and Management Sciences, 30 (1-2), 83-109. Paper
  • Liang, H., Wu, H.*, (2010), Correction on “Parameter Estimation for Differential Equation Models Using a Framework of Measurement Error in Regression Models (JASA, 103, 1570-1583),” Journal of the American Statistical Association, 105, 1636.
  • Baer, J., Santiago, F., Yang, H., Wu, H., Holden-Wiltse, J., Treanor, J., Topham, D.J. (2010), B Cell Responses to H5 Influenza HA in Human Subjects Vaccinated with Drifted Variants,  Vaccine, 28, 907-915. PMID: 19932673
  • Liang, H., Miao, H., and Wu, H. (2010), Estimation of constant and time-varying dynamic parameters of HIV infection in a nonlinear differential equation model, Annals of Applied Statistics, 4, 460-483. PMID: 20556240 | PMCID: PMC2885820Patient 1 Data | Patient 2 Data
  • Wood, R., Liang, H., Wu, H., Middelkoop, K., Oni, T., Rangaka, M.X., Wilkinson, R.J., Bekker, L.G., Lawn, S. D. (2010), Changing prevalence of Tuberculosis infection with increasing age in high-burden townships in South Africa, the International Journal of Tuberculosis and Lung Disease, 14, 406-412. PMID: 20202297
  • Ma, J., Dykes, C., Wu, T., Huang, Y., Demeter, L., Wu, H. (2010), vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments, BMC Bioinformatics, 11:261. PMID: 20482791 | PMCID: PMC2882933
  • Xue, H., Miao, H., Wu, H. (2010), Sieve Estimation of Constant and Time-Varying Coefficients in Nonlinear Ordinary Differential Equation Models by Considering Both Numerical Error and Measurement Error, Annals of Statistics, 38, 2351-87. PMID:21132064
  • Miao, H., Hollenbaugh, J.A., Zand, M., Holden-Wiltse, J., Mosmann, T.R., Perelson, A.S., Wu, H., Topham, D.J. (2010), Quantifying the Early Immune Response and Adaptive Immune Response Kinetics in Mice Infected with Influenza A Virus, Journal of Virology, 84, 6687-6698. PMID: 20410284 | Data | GUI Tool
  • Wang, J., Liang, H., Bacheler, L., Wu, H., Deriziotis, K., Demeter, L.M., Dykes, C. (2010), The Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz Stimulates Replication of Human Immunodeficiency Virus Type 1 Harboring Certain Non-nucleoside Resistance Mutations, Virology, 402, 228-237. PMID: 20399480
  • Dykes, C., Wu, H., Sims, M., Holden-Wiltse, J., Demeter, L. (2010), Human immunodeficiency virus type 1 protease inhibitor drug-resistant mutants give discordant results when compared in single-cycle and multiple-cycle fitness assays, Journal of Clinical Microbiology, 48, 4035-4043. PMID: 20826651
  • Huang, Y., Wu, H., Acosta, P. (2010), Hierarchical Bayesian Inference for HIV Dynamic Differential Equation Models Incorporating Multiple Treatment Factors, Biometrical Journal, 52(4), 470-486. PMID: 20661953

2009

  • Miao, H., Dykes, C., Demeter, L., Wu, H. (2009), Differential Equation Modeling of HIV Viral Fitness Experiments: Model Identification, Model Selection, and Multi-Model Inference, Biometrics, 65, 292-300. PMID: 18510656 | GUI Tool
  • Eron, J.J., Park, J.G., Haubrich, R.,  Aweeka, F., Bastow, B., Pakes, G.E., Yu, S., Wu, H., and Richman, D.D. for the ACTG5126 Study Team (2009), Predictive Value of Pharmacokinetic-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PI) in Human Immunodeficiency Virus-Infected Subjects Failing Prior PI Therapy, Antimicrobial Agents and Chemotherapy, 53, 2335-2341. PMID: 19307363
  • Lee, H.Y., Topham, D.J., Park, S.Y., Hollenbaugh, J., Treanor, J., Mosmann, T.R., Jin, X., Ward, B., Miao, H., Holden-Wiltse, J.,  Perelson, A.S.,  Zand, M.,  Wu, H. (2009), Simulation and Prediction of the Adaptive Immune Response to Influenza A Virus Infection, Journal of Virology, 83, 7151-7165. PMID: 19439465 | PMCID: PMC2704765 | Data | GUI Tool
  • Lee, H.Y., Hawkins, E., Zand, M.S., Mosmann, T., Wu, H., Hodgkin, P.D., Perelson, A.S. (2009), Interpreting CFSE Obtained Division Histories of B Cells in Vitro with Smith-Martin and Cyton Type Models, Bulletin of Mathematical Biology, 71, 1649-1670. PMID: 19381725

2008

  • Huang, Y. and Wu, H. (2008), Bayesian Experimental Design for Long-Term Longitudinal HIV Dynamic Studies, Journal of Statistical Planning and Inference, 138, 105-113. PMCID: PMC3225901Data | Fortran Code
  • Wu, L., Hu, J.X., and Wu, H. (2008), Joint Inference for Nonlinear Mixed-Effects Models and Time to Event at the Presence of Missing Data, Biostatistics, 9(2), 308-320. PMID: 17728318
  • Chen, J. and Wu, H. (2008), Efficient Local Estimation for Time-varying Coefficients in Deterministic Dynamic Models with Applications to HIV-1 Dynamics, Journal of the American Statistical Association, 103, 369-384. PaperData | VDM_main.c
  • Wu, H., Zhu, H., Miao, H., and Perelson, A.S. (2008), Parameter Identifiability and Estimation of HIV/AIDS Dynamic Models, Bulletin of Mathematical Biology, 70(3), 785-799. PMID: 18247096
  • Miao, H., Dykes, C., Demeter, L.M., Cavenaugh, J., Park, S.Y., Perelson, A.S., and Wu, H. (2008), Modeling and Estimation of Kinetic Parameters and Replicative Fitness of HIV-1 from Flow-Cytometry-Based Growth Competition Experiments, Bulletin of Mathematical Biology, 70, 1749-1771. PMID: 18648886 | GUI Tool
  • Chen, J. and Wu, H. (2008), Estimation of time-varying parameters in deterministic dynamic models, Statistica Sinica, 18, 987-1006. Paper | Data
  • Liang, H., Wu, H., Zou, G. (2008), A Note on Conditional AIC for Linear Mixed-Effects Models, Biometrika, 95, 773-778. PMID: 19122890 | PMCID: PMC2572765
  • Huang, Y., Liang, H., and Wu, H. (2008), Identifying significant covariates for anti-HIV treatment response: mechanism-based differential equation models and empirical semiparametric regression models, Statistics in Medicine, 27, 4722-4739. PMID: 18407583 | PMCID: PMC2574674
  • Liang, H., Wu, H., (2008), Parameter Estimation for Differential Equation Models Using a Framework of Measurement Error in Regression Models, Journal of the American Statistical Association, 103, 1570-1583. PMID: 19956350 | PMCID: PMC2631937

2007

  • Jin, X., Wu, H. and Smith, H. (2007), APOBEC3G Levels Predict Rates of Progression to AIDS, Retrovirology, 4:20. Paper | PMID: 17374143 | PMCID: PMC1832211
  • Flanigan, R.M., Nawoczenski, D.A., Chen, L., Wu, H., and DiGiovanni, B.F. (2007), The Influence of Foot Position on Stretching of the Plantar Fascia, Foot & Ankle, 28, 815-822. PMID: 17666175
  • Palumbo, P., Wu, H., Chadwick E. et al. (2007), Virologic Response to Potent Antiretroviral Therapy and Modeling of HIV Dynamics in Early Pediatric Infection, The Journal of Infectious Diseases, 196, 23-29. PMID: 17538879
  • Wu, H. (2007). Discussion of “Parameter Estimation for Differential Equations: A Generalized Smoothing Approach,” by J. O. Ramsay, G. Hooker, D. Campbell and J. Cao. Journal of the Royal Statistical Society, Ser. B. 69, 789. Paper
  • Zhu, H. and Wu, H. (2007), Estimation of Smoothing Time-Varying Parameters in State Space Models, Journal of Computational and Graphical Statistics (JCGS), 16(4), 813-832. Paper

2006

  • Huang, Y. and Wu, H. (2006), “A Bayesian Approach for Estimating Antiviral Efficacy in HIV Dynamic Models," Journal of Applied Statistics, 33, 155-174. PaperData | Fortran Code
  • Wu, H., Huang, Y., Dykes, C., Liu, D., Ma, J., Perelson, A.S., Demeter, L. (2006), Modeling and Estimation of Replication Fitness of Human Immunodeficiency Virus type 1 in Vitro Experiments Using a Growth Competition Assay, Journal of Virology, 80, 2380-2389. PMID: 16474144 | PMCID: PMC1395363
  • Park, J.G. and Wu, H. (2006), “Backfitting and Local Likelihood Methods for Nonparametric Mixed-Effects Models with Longitudinal Data," Journal of Statistical Planning and Inference, 136, 3760-3782. Paper | Data
  • Huang, Y., Liu, D. and Wu, H. (2006), Hierarchical Bayesian Methods for Estimation of Parameters in a Longitudinal HIV Dynamic System, Biometrics, 62, 413-423. PMID: 16918905 | PMCID: PMC2435289DataFortran Code | Technical Report
  • Wu, H., Huang, Y. and Acosta, E.P. et al. (2006), Pharmacodynamics of Antiretroviral Agents in HIV-1 Infected Patients Using Viral Dynamic Models That Incorporate Drug Susceptibility and Adherence, Journal of Pharmacokinetics and Pharmacodynamics, 33, 399-419. PMID: 16583266 | Data
  • Liu, D., Yu, J., Reichman, R., Chang, X., Wu, H., Jin, X. (2006), Statistical Determination of Threshold for Cellular Division in the CFSE-Labeling Assay, Journal of Immunological Methods, 312, 126-136. PMID: 16712866
  • Dykes, C., Wang, J., Jin, X., Planelles, V., An, D.S., Tallo, A., Huang, Y., Wu, H., Demeter, L.M. (2006), Evaluation of a Multiple-Cycle, Recombinant Virus, Growth Competition Assay that Uses Flow Cytometry to Measure Replication Efficiency of Human Immunodeficiency Virus Type 1 in Cell Culture, Journal of Clinical Microbiology, 44, 1930-1943. PMID: 16757582 | PMCID: PMC1489405
  • Treanor, J., Wu, H., Liang, H., and Topham, D.J. (2006), Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults, Vaccine, 24, 6913-6923.PMCID:17014939

2005

  • Wu, H. (2005), “Statistical Methods for HIV Dynamic Studies in AIDS Clinical Trials," Statistical Methods in Medical Research, 14, 171-192. Paper
  • Sun, Y. and Wu, H. (2005), “Semiparametric Time-Varying Coefficients Regression Model for Longitudinal Data," Scan. J. Statist., 32, 21-47. Paper | Data
  • Wu, H., Huang, Y. and Acosta, E.P. et al. (2005), Modeling Long-Term HIV Dynamics and Antiretroviral Response: Effects of Drug Potency, Pharmacokinetics, Adherence, and Drug Resistance, JAIDS, 39, 272-283. PMID: 15980686Data | GUI Tool

2004

  • Wu, H. and Liang, H. (2004), “Backfitting Random Varying-Coefficient Models with Time-Dependent Smoothing Covariates," Scan. J. Statist., 31, 3-19. Paper | Data | S+ code
  • Wu, H., Lathey, J., Ruan, P., et al. (2004), “Relationship of Plasma HIV-1 RNA Dynamics to Baseline Factors and Virological Responses to Highly Active Antiretroviral Therapy in Adolescents (Aged 12-22 Years) Infected through High-Risk Behavior," Journal of Infectious Diseases, 189, 593-601. PMID: 14767811
  • Wu, H., Zhao, C. and Liang, H. (2004), “ Comparison of Linear, Nonlinear and Semiparametric Models for Estimating HIV Dynamic Parameters," Biometrical Journal, 46, 233-245. Paper
  • Acosta, E.P., Wu, H., Hammer, S.M. et al. (2004), “Comparison of Two Indinavir/Ritonavir Regimens in the Treatment of HIV-Infected Individuals," JAIDS, 37, 1358-1366. PMID: 15483465

2003

  • Liang, H., Wu, H., and Carroll, R.J. (2003), “The Relationship Between Virologic and Immunologic Responses in AIDS Clinical Research Using Mixed-Effects Varying-Coefficient Semiparametric Models with Measurement Error," Biostatistics, 4, 297-312. Paper | Data
  • Hamzeh, F.M., Benson, C., Gerber, J., Currier, J., McCrea, J., Deutsch, P., Ruan, P., Wu, H., Lee, J., Flexner, C. (2003), "Steady-State Pharmacokinetic Interaction of Modified-Dose Indinavir and Rifabutin," Clinical Pharmacology and Therapeutics, 73, 159-169. PMID: 12621381
  • DiCenzo, R., Forrest, A., Squires, K.E., Hammer, S.M., Fischl, M.A., Wu, H., Cha, R., Morese, G.D. and the Adult AIDS Clinical Trials Group Protocol 368/886 Study Team (2003), “Indinavir, Efavirenz and Abacavir Pharmacokinetics in Human Immunodeficiency Virus-Infected Subjects," Antimicrobial Agents and Chemotherapy, 47, 1929-1935. PMID: 12760869 | PMCID: PMC155818
  • Sun, Y. and Wu, H. (2003), “AUC-Based Tests for Nonparametric Functions with Longitudinal Data," Statistica Sinica, 13, 593-612. Paper
  • Huang, Y., Rosenkranz, S., Wu, H. (2003), “Modeling HIV Dynamics and Antiviral Responses with Consideration of Time-Varying Drug Exposures, Adherence and Phenotypic Sensitivity," Mathematical Biosciences, 184, 165-186. PMID: 12832146 | GUI Tool
  • Wu, H., Mellors, J., Ruan, P. et al. (2003), “Viral Dynamics and Their Relations to Baseline Factors and Longer Term Virologic Responses in Treatment-Naive HIV-1-Infected Patients Receiving Abacavir in Combination with HIV-1 Protease Inhibitors," JAIDS, 32, 557-564. PMID: 12902798
  • Hass, D.W., Wu, H., Li, H. et al. (2003), “MDR1 Gene Polymorphisms and Phase 1 Viral Decay during HIV-1 Infection: An Adult AIDS Clinical Trials Group Study," JAIDS, 34, 295-298. Paper
  • Zhang, Y., Liu, W., and Wu, H. (2003), “ A simple nonparametric two-sample test for the distribution function of event time with interval censored data," Journal of Nonparametric Statistics, 15, 643-652.Paper | Data

2002

  • Wu, H. and Wu, L. (2002), “Identification of Significant Host Factors for HIV Dynamics Modeled by Nonlinear Mixed-Effect Models," Statistics in Medicine, 21, 753-771. PMID: 11870815 | Data
  • Wu, H. and Ding, A.A. (2002), “Design of Viral Dynamic Studies for Efficiently Assessing Potency of Anti-HIV Therapies in AIDS Clinical Trials," Biometrical Journal, 2, 175-196. Paper
  • Wu, H. and Zhang, J.T. (2002), “Local Polynomial Mixed-Effects Models for Longitudinal Data," Journal of the American Statistical Association, 97, 883-897. Paper | Data
  • Wu, L. and Wu, H. (2002), “ Missing time-dependent covariates in human immunodeficiency virus dynamic models," Journal of the Royal Statistical Society, Series C (Applied Statistics), 51, 297-318. Paper | Data
  • Wu, H. and Zhang, J.T. (2002), “The Study of Long-Term HIV Dynamics Using Semiparametric Nonlinear Mixed-Effects Models," Statistics in Medicine, 21, 3655-3675. PMID: 12436462 | Data

2001

  • Ding, A.A. and Wu, H. (2001), “Assessing Antiviral Potency of Anti-HIV Therapies in Vivo by Comparing Viral Decay Rates in Viral Dynamic Models," Biostatistics, 2, 13-29 Paper
  • Wu, H. and Wu, L. (2001), “A Multiple Imputation Method for Missing Covariates in Non-linear Mixed-effects Models with Application to HIV Dynamics," Statistics in Medicine, 20 (12), 1755-1769. PMID: 11406839 | Data
  • Wu, H., Connick E., Kuritzkes, D.R. et al. (2001), “Multiple CD4+ Cell Kinetic Patterns and Their Relationships with Baseline Factors and Virologic Responses in HIV-1 Type 1 Patients Receiving Highly Active Antiretroviral Therapy," AIDS Research and Human Retroviruses, 17(13), 1237-1246. PMID: 11559422

2000

  • Ding, A.A. and Wu, H. (2000), “A Comparison Study of Models and Fitting Procedures for Biphasic Viral Dynamics in HIV-1 Infected Patients Treated with Antiviral Therapies," Biometrics, 56, 293-300. PMID: 10783809 | Data
  • Kuritzkes, D., Sevin A., Young, B., Bakhtiari, M., Wu, H., Clair, M.S., Connick, E., Landay, A.L., Spritzler, J., Kessler, H., and Lederman, M.M. (2000), “Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315. ACTG Protocol 315 Team.," Journal of Infectious Diseases, 181, 491-497. PMID: 10669331
  • Wu, H. and Tan, W.Y. (2000), “Modelling the HIV Epidemic: A State-Space Approach," Mathematical and Computer Modelling, 32, 197-215. (Epidemiology Young Investigator Award). Paper

1999

  • Wu, H. and Ding, A. (1999), “Population HIV-1 Dynamics in Vivo: Applicable Models and Inferential Tools for Virological Data from AIDS Clinical Trials," Biometrics, 55, 410-418. PMID: 11318194 | Data
  • Wu, H., Kuritzkes, D.R., and McClernon, D.R. et al. (1999), “Characterization of Viral Dynamics in Human Immunodeficiency Virus Type 1-Infected Patients Treated with Combination Antiretroviral Therapy: Relationships to Host Factors, Cellular Restoration and Virological Endpoints," Journal of Infectious Diseases, 179(4):799-807. PMID: 10068574 | Data
  • Luzuriaga, K., Wu, H., and McManus, M. et al. (1999), “Dynamics of Human Immunodeficiency Virus Type-1 Replication in Vertically-Infected Infants," Journal of Virology, 73, 362-367. PMID: 9847340 | PMCID: PMC103841
  • Wu, H., Ding, A. and DeGruttola, V. (1999), “Why are the decay rates in plasma HIV-1 different for different treatments and in different patient populations?" AIDS, 13 (3): 429-430. PMID: 10199240
  • Wu, H. (1999), “How Frequently Should Viral Load be Monitored to Evaluate Antiretroviral Therapies in AIDS Clinical Trials?" Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 20, 97-99. PMID: 9928739
  • Ding, A.A. and Wu, H. (1999), “Relationships between Antiviral Treatment Effects and Biphasic Viral Decay Rates in Modeling HIV Dynamics," Mathematical Biosciences, 160, 63-82. PMID: 10465932 | Data
  • Wu, H., Ruan, P., Ding, A.A., Sullivan, J.L. and Luzuriaga, K. (1999), “Inappropriate Model-Fitting Methods May Lead To Significant Underestimates of Viral Decay Rates in HIV Dynamic Studies," Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 21, 426-428. PMID: 10458627
  • Spear, GT, Olinger G, Sullivan B, Landay AL, Kessler, H, Connick E, Kuritzkes D, St. Clair M, Spritzler J, Wu H, Lederman MM (1999) “Alteration of complement protein levels after antiretroviral therapy in HIV-infected persons," AIDS Research and Human Retroviruses, 15, 1713-15. PMID: 10606095

1998

  • Huffer, F.W. and Wu, H. (1998), “Markov Chain Monte Carlo for Autologistic Regression Models with Application to the Distribution of Plant Species," Biometrics, 54, 509-524. Paper
  • Tan, W.Y. and Wu, H. (1998),“Stochastic Modeling of the Dynamics of CD4+ T Cell Infection by HIV and some Monte Carlo Studies," Mathematical Biosciences, 147, 173-205. PMID: 9433062
  • Wu, H., Ding, A. and DeGruttola. V. (1998), “Estimation of HIV Dynamic Parameters," Statistics in Medicine, 17, 2463-2485. PMID: 9819839

1997

  • Wu, H. and Huffer, F.W. (1997), “Modelling the Distribution of Plant Species Using the Autologistic Regression Model," Environmental and Ecological Statistics, Vol. 4, No.1, 49-64. (First Prize, Student Paper Awards by Section on Statistics and the Environment of ASA) Paper
  • George, E.O. and Wu, H. (1997), “Testing for Treatment Related Trend with Partially Exchangeable Clustered Data," Biometrics, 53, 479-487. PMID: 9192447

Thesis, Proceedings, and Book Chapters

Wu, H. (1994), “Regression Models for Spatial Binary Data with Application to the Distribution of Plant Species," Ph.D. dissertation, Department of Statistics, Florida State University.

Wu, H. and Tan, W.Y (1996),“Modeling and Monitoring the Progression of HIV Infection Using Nonlinear Kalman Filter," ASA 1996 Proceedings of the Biometrics Section, 372-377.

Tan, W.Y. and Wu, H. (1997), “A Stochastic Model of the Pathogenesis of HIV at the Cellular Level and Some Monte Carlo Studies," Simulation in the Medical Sciences, Edited by Anderson, J.G. and Katzper, M., The Society for Computer Simulation International, the 1997 SCS Western Multiconference, 78-86.

Ding, A. and Wu, H. (1997), “Modeling HIV Dynamics with Treatment of Reverse Transcriptase Inhibitor Drugs," ASA 1997 Proceedings of the Epidemiology Section, 52-57.

Wu, H. and Ding A.A. (1999), “Assessing Anti-HIV Therapies Using Viral Dynamics: An Overview," Concepts and Applications of Systemics, Cybernetics and Informatics, Edited by Torres, M., Sanchez, B., and Wills, E., Proceedings of 3rd World Multi-conference on Systemics, Cybernetics and Informatics, Vol. 8, 490-497.

Wu, H., Zhang, B., and Spritzler, J. (1999), “Modeling and Analyzing Cellular Kinetics for HIV-infected Patients Treated with Potent Antiviral Therapies in AIDS Clinical Trials," ASA 1999 Proceedings of the Biometrics Section, 123-128.

Ding, A. and Wu, H. (1999), “Statistical Tests in Nonlinear Mixed-Effect Models with Application to Potency Comparison of Anti-HIV Therapies," ASA 1999 Proceedings of Biopharmaceutical Statistics Section, 58-63.

Wu, H. and Zhao, S. (2002), “Chapter 17. Models for Infectious Diseases,"Advanced Medical Statistics, Fang, J.Q. and Lu, Y. (editors). World Sciences Publisher, Singapore.

Huang, Y. and Wu, H. (2004), “Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials," Advanced Methods of Pharmacokinetic & Pharmacodynamic Systems Analysis, Volume III, edited by David Z. D’Argenio. New York: Kluwer Academic Publishers, Page 221-237.

Huang, Y. and Wu, H. (2005), “Bayesian Estimation of Individual Parameters in an HIV Dynamic Model Using Long-Term Viral Load Data," Deterministic and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention, edited by W.Y. Tan and H. Wu. Singapore: World Scientific.

Huang, Y. and Wu, H. (2008), “HIV Dynamics Modeling and Prediction of Clinical Outcomes in AIDS Clinical Research,” Statistical Advances in the Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics, edited by Atanu Biswas, Sujay Datta, Jason P. Fine, and Mark R. Segal.  New York, Wiley InterScience.

Invited Talks and Peer-Reviewed Presentations

2017

  • Invited seminar talk, College of Science and Engineering, University of Houston-Clear Lake, January 27, 2017.
  • Invited plenary talk, Workshop on Parameter Estimation and Uncertainty Quantification for Dynamic Systems, University of Pittsburg, Pittsburgh, March 5-6, 2017.
  • Invited seminar talk, Department of Statistics & Actuarial Science, Simon Fraser University, Vancouver, Canada, April 7, 2017.
  • Invited talk, 2017 SIAM Conference on Applications of Dynamic Systems, Snowbird, Utah, USA, May 21-25, 2017.

2016                                                                            

  • Invited speaker, ENAR 2016 Spring Meeting, Austin, TX, March 6-9, 2016.
  • Invited speaker, Big Data & Data Analytics Conference, Texas Fresh Air, San Antonio, TX, March 30-31, 2016.
  • Invited seminar speaker, Department of Applied Mathematics, Xi’an Jiaotong University, Xi’an, China, June 3, 2016. 
  • Invited seminar speaker, College of Mathematical and Information Science, Shaanxi Normal University, Xi'an, China, June 3, 2016. 
  • Invited talk, 2016 ICSA Applied Statistics Symposium, Atlanta, GA, June 12-15, 2016.
  • Invited talk, XXVIIIth International Biometric Conference (IBC2016), Victoria, Canada, July 10-15, 2016.
  • Keynote talk, Tutorial Workshop on Parameter Estimation for Biological Models, NC State University, Raleigh, NC, USA, July 28-31, 2016.
  • Invited speaker, the 2016 Joint Statistical Meetings, Chicago, IL, USA, July 30- August 4, 2016.
  • Invited seminar speaker, Department of Molecular and Computational Biology, University of Southern California, CA, USA, September 8, 2016.
  • Invited talk, 2016 International Conference on Big Data and Information Analytics, Changsha, China, October 20-23, 2016,
  • Invited seminar talk, Institute of Computational Mathematics and Scientific/Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing, China, October 26, 2016.
  • Invited talk, CMStatistics 2016, 9th International Conference of the ERCIM Working Group on Computational and Methodological Statistics, Seville, Spain, December 9-11, 2016.
  • Invited speaker, The 10th ICSA International Conference on Global Growth of Modern Statistics in the 21st Century, Shanghai, China, December 19-22, 2016.
  • Invited seminar speaker, Mathematics and Science College, Shanghai Normal University, Shanghai, China, December 20, 2016.
  • Invited speaker, Mathematics and Statistics in Medical Imaging Applications and Big Data Integration Workshop, Tsinghua Sanya International Mathematics Forum, Sanya, China, December 26-30, 2016.

2015

  • Invited colloquium speaker, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS. March 2, 2015.
  • Invited Colloquium speaker, Department of Statistics, Florida State University, Tallahassee, FL, April 3, 2015.
  • Lecturer, 2015 Summer School on Computational Immunology, University of Rochester, Rochester, NY, June 1-4, 2015.
  • Invited speaker, 2015 Symposium on Immune Modeling in the Big Data Era, University of Rochester, Rochester, NY, June 4-5, 2015.
  • Keynote speaker, 2015 Biomathematics Summer School, Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China, July 14-18, 2015.
  • Invited talk, School of Life Sciences, Fudan University, Shanghai, P.R. China, July 20, 2015.
  • Invited talk, Key Lab of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China, July 21, 2015
  • Invited talk, Institute of Computational Mathematics and Scientific/Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing, China, July 27, 2015.
  • Invited Colloquium speaker, Department of Biological Statistics and Computational Biology, and Department of Statistical Science, Cornell University, Ithaca, NY, September 23, 2015.
  • Invited seminar speaker, College of Statistics and Management, Shanghai University of Finance and Economics, Shanghai, China, November 2, 2015.
  • Invited speaker, NIH/NIAID Workshop on Infectious Diseases Research: Quantitative Methods and Models in the Era of Big Data, Bethesda, MD, November 9-10, 2015.

2014

  • Invited seminar speaker, Department of Mathematics and Statistics, York University, Toronto, Canada, March 21, 2014.
  • Keynote speaker, 2014 Biomathematics Summer School, Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China, July 21-August 15, 2014.
  • Invited speaker, Workshop on Statistics and Nonlinear Dynamics in Biology and Medicine, the Banff International Research Station for Mathematical Innovation and Discovery (BIRS), Banff, Canada, July 27-August 1, 2014.
  • Invited talk, SIAM Conference on the Life Sciences, Charlotte, North Carolina, August 4-7, 2014.
  • Invited to lead one-day FDA training workshop, Computational Modeling of Biological Systems to Quantitatively Understand and Efficiently Evaluate Therapeutic Intervention Strategies for Complex Diseases, 2014 FDA OBE Training Workshop Series, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, Sept 2, 2014.
  • Invited talk, Zhejiang University Medical School, Hangzhou, China, Nov. 27, 2014.

2013

  • Invited talk, The ASA Buffalo Chapter and Department of Mathematics and Statistics, Canisius College, Buffalo, New York. April 29, 2013. 
  • Keynote speaker, 1st Workshop on Virus Dynamics, Frankfurt, Germany, July 15-16, 2013.
  • Invited talk of a contributed session, 29th European Meeting of Statisticians, Budapest, Hungary, July 20-15, 2013.
  • Invited seminar talk, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, September 9, 2013.
  • Invited talk, The 9th International Conference on Numerical Optimization and Numerical Algebra, Changchun, Jilin, China, Sept 12-15, 2013.
  • Invited seminar talk, College of Computer and Informatics Sciences, Southwest University, Chongqing, China, September 18, 2013.
  • Invited talk, 2013 Fall Central Section Meeting, American Mathematical Society, Washington University, St. Louis, MO, October 20, 2013.
  • Invited speaker, ENAR 2013 Spring Meeting, Orlando, FL, March 10-13, 2013.
  • Invited talk, Department of Statistical Sciences, University of Toronto, Canada. March 28, 2013.

2012

Invited speaker, Workshop: Recent Advances in Statistical Inference for Mathematical Biology, Mathematical Biosciences Institute, The Ohio State University. February 20-24, 2012.

Invited speaker, ENAR 2012 Spring Meeting, Washington, DC, April 1-4, 2012.

Invited speaker, Interdisciplinary Workshop between Mathematics and Biology, Center for Optimization and Its Applications, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, May 7-8, 2012.

Invited seminar speaker, College of Mathematical and Information Science, Shaanxi Normal University, Xi'an, China, May 10, 2012. 

Invited seminar speaker, Department of Applied Mathematics, Xi’an Jiaotong University, Xi’an, China, May 11, 2012. 

Invited seminar speaker, BGI, Shenzhen, China, May 16, 2012.

Invited seminar speaker, Shanghai Medical College, Fudan University, Shanghai, China, May 18, 2012.

Peer-reviewed talk, The 6th International Conference on Bioinformatics and Biomedical Engineering (iCBBE2012), Shanghai, China, May 17-20, 2012.

Invited seminar speaker, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, May 21, 2012.

Invited seminar speaker, Mathematics and Science College, Shanghai Normal University, Shanghai, China, May 21, 2012.

Invited seminar speaker, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China, May 25, 2012.

Co-Chair of the organization committee and lecturer, 2012 Summer School on Computational Immunology, University of Rochester, Rochester, NY, June 10-14, 2012.

Co-Chair of the organization committee and invited speaker, 2012 Symposium on Modeling Immune Responses from Complex Data, University of Rochester, Rochester, NY, June 14-15, 2012.

Invited talk, 8th International Purdue Symposium on Statistics, Purdue University, West Lafayette, Indiana, June 20-24, 2012.

Invited talk, the 21st Applied Statistics Symposium, Boston, MA, June 23-26, 2012.

2011

Invited speaker, Dynamics of Networks Workshop, SAMSI, RTP, North Carolina, January 12, 2011.

Invited colloquium speaker, Department of Biostatistics, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina, January 12, 2011.

Invited speaker, Undergraduate Workshop on Analysis of Object Data at the Statistical and Applied Mathematical Sciences Institute (SAMSI), RTP, North Carolina, February 25, 2011.

Invited speaker, 2011 SIAM Great Lakes Conference on Modeling and Numerical PDEs in Mathematical Biology and Applications, Oakland University, Rochester, Michigan, April 16, 2011.

Oral presentation, 5th Annual CEIRS Network Meeting, Atlanta, Georgia, April 18-20, 2011.

Invited speaker, Applied Inverse Problems Conference, Texas A&M University, College Station, TX, May 23-27, 2011.

Invited speaker, AOOD Transition Workshop, SAMSI, RTP, North Carolina, June 9-11, 2011.

Invited Speaker, IMS-China International Conference on Statistics and Probability 2011, Xi’an, China, July 8-11, 2011.

Invited Seminar, Department of Applied Mathematics, Xi’an Jiaotong University, Xi’an, China, July 9-10, 2011. 

Invited Seminar, Institute of Computational Mathematics and Scientific/Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing, China, July 17, 2011.

Invited talk, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration (FDA), August 8, 2011.

Invited talk, Department of Statistics, Texas A&M University, College Station, TX, October 3, 2011.

Invited panel speaker on Non-Human Model Systems for Testing the Effectiveness of Medical Countermeasures, Biosecurity Meeting, Center for Science, Technology, and Security Policy, American Association for the Advancement of Science (AAAS), Washington DC, October 19, 2011.

Invited seminar speaker, School of mathematical Sciences, Rochester Institute of Technology, Rochester, NY, October 21, 2011.

2010

Invited speaker, the 2010 WNAR/IMS Spring Meeting, Seattle, WA, June 20-23, 2010.

Invited speaker, The First Joint Biostatistics Symposium, Beijing, China, July 17-18, 2010.

Invited speaker, the 2010 Joint Statistical Meetings, Vancouver, Canada, August 1-5, 2010.

Invited colloquium speaker, The Center for Nonlinear Studies (CNLS), Los Alamos National Laboratory, October 25, 2010.

Invited speaker, Interface Functional & Longitudinal Data Analysis Workshop, the Statistical and Applied Mathematical Sciences Institute (SAMSI), RTP, North Carolina, November 8-10.2010.

Invited speaker, Molecular Basis of Disease Distinguished Lecture Series, Georgia State University, December 2, 2010.

Invited colloquium speaker, Department of Mathematics and Statistics, Georgia State University, December 2, 2010

Invited seminar speaker, Department of Electrical and Computer Engineering, University of Delaware, Newark, DE 19716, February 19, 2010.

Keynote Speaker, Modeling Dynamic Systems Workshop, University of California, Davis, CA 95616, March 13, 2010.

Invited speaker, ENAR 2010 Spring Meeting, New Orleans, Louisiana, March 21-24, 2010.

Invited speaker, Lectureship Series, Center for Statistical Sciences, Brown University, Providence, RI, USA, April 19, 2010.

2009

Invited speaker, the 50th Anniversary Celebration of FSU’s Statistics Department, Tallahassee, Florida, April 17-18, 2009.

Invited speaker, Workshop on Statistical Methods for Dynamic System Models, Vancouver, Canada, June 4-6, 2009.

Invited speaker and round table discussion leader, ICSA 2009 Applied Statistics Symposium, San Francisco, CA, June 21-23, 2009.

Invited speaker, Symposium on Multi-Scale Modeling of Host/Pathogen Interactions, University of Pittsburgh, Pittsburgh, PA, June 23-25, 2009.

Invited speaker, 2009 International Conference on Financial Statistics and Financial Econometrics, Chengdu, China, July 8-10, 2009.

Invited speaker and session organizer, 2009 Joint Statistical Meetings, Washington DC, August 1-6, 2009.

Invited speaker, 57th Session of the International Statistical Institute, Durban, South Africa, August 16-22, 2009.

Invited speaker, 22nd Workshop on Health and Complex Systems, Lyon, France, November 28-December 2, 2009.

Peer-reviewed oral presentation, 2nd International Conference on Infectious Disease Dynamics, Athens, Greece, December 2-4, 2009.

2008

Invited speaker for a Special Emphasis Panel organized by the NIAID/NIH Project officer, 2008 ENAR Spring Meetings, Arlington, Virginia, March 16-19, 2008.

Invited speaker, Atlantic Coast Symposium on the Mathematical Sciences in Biology and Biomedicine, North Carolina State University, Raleigh, North Carolina, April 24-26, 2008.

Invited talks, Academy of Mathematics and Systems Sciences, Chinese Academy of Sciences, Beijing, China, May 26, 2008.

Invited session organizer, IMS-China International Conference on Statistics and Probability 2008, Hangzhou, China, June 11-13, 2008.

Invited speaker, Computational & Systems Immunology Symposium, Duke University, Durham, North Carolina, June 25-26, 2008.

Invited talk, the XXIVth International Biometric Conference, Dublin, Ireland, July 13-18, 2008.

Invited Lecturer for the Introductory Overview Lecture (IOL), Session Chair and Organizer, the 2008 Joint Statistical Meetings, Denver, Colorado, August 2-7, 2008.

Invited seminar speaker, Center for Computational Biology & Bioinformatics, Indiana University School of Medicine, Indianapolis, October 13, 2008.

Invited guest speaker, Biostatistics Research Branch, NIAID/NIH, Bethesda, Maryland, December 2, 2008.

2007

Invited colloquium speaker, Division of Biostatistics, Yale School of Public Health, New Haven, Connecticut, January 23, 2007.

Invited colloquium speaker, Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA, February 7, 2007.

Invited speaker, ICSA 2007, Applied Statistics Symposium, International Chiese Statistical Association, Raleigh, North Carolina, June 3-6, 2007.

Invited speaker, Symposium on Emerging Science of Emerging Pathogens: From Atoms to the World, New York City, June 7, 2007.

Invited speaker, 2007 Biodefense Immune Modeling Summer School, Carnegie Mellon University and University of Pittsburg, Pittsburg, Pennsylvania, June 17-22, 2007.

Invited speaker, Workshop on Statistical Methods for Modeling Dynamic Systems, University of Montreal, Montreal, Quebec, Canada, July 9-13, 2007.

Invited speaker, Mini-symposium at the 6th International Congress on Industrial and Applied Mathematics, Zurich, Switzerland, July 16-20, 2007.

Invited speaker, Topic-contributed session, 2007 Joint Statistical Meetings, Salt Lake City, Utah, July 29-August 2, 2007.

Invited speaker, 7th International Workshop on Pharmacodynamics of Anit-Cancer agents, Guanacaste, Costa Rica, September 16-20, 2007.

Invited speaker, International Conference on Advances in Interdisciplinary Statistics and Combinatorics, Greensboro, North Carolina, October 12-14, 2007.

Invited colloquium speaker, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada, October 19, 2007.

Seminar Speaker, Department of Biostatistics, The University of Kansas Medical Center, Kansas City, Kansas, November 20, 2007.

2006

Peer-reviewed poster presentation, the 13th Conference on Retroviruses and Opportunistic Infections, Denver, Colorado, February 5-8, 2006.

Invited talk, Department of Preventive Medicine and Biometrics, University of Colorado Health Science Center, Denver, Colorado, February 9, 2006.

Colloquium speaker, Department of Epidemiology and Biostatistics College of Public Health, University of South Florida, Tampa, Florida, March 22, 2006.

Session Organizer and Speaker, the ICSA 2006 Applied Statistics Symposium, University of Connecticut, Storrs, Connecticut, June 14-17, 2006.

Organizer/Host and Invited Speaker, the First Biodefense Immune Modeling Symposium, Rochester, New York, June 22-23, 2006.

Invited talk, Department of Life Science and Engineering, Bioengineering Research Center, Harbin Institute of Technology, Harbin, China, July 6, 2006.

Invited Speaker, International Conference on Frontiers in Statistics, Biostatistics and Bioinformatics, Changchun, China, July 7-8, 2006.

Invited Speaker, the Mini-symposium at the 2006 SIAM Annual Meeting, Boston, MA, July 10-14, 2006.

Invited talk, the Topic Contributed Session, the XXIII International Biometric Conference, Montreal, Quebec, Canada, July 16-21, 2006.

Invited Speaker, the Mini-symposium at the Joint SIAM-SMB Conference on the Life Sciences, Raleigh, North Carolina, July 31-August 4, 2006.

Organizer and Speaker, the Later-Breaking Session, the 2006 Joint Statistical Meetings, Seattle, Washington, August 6-10, 2006.

Colloquium Speaker, Department of Statistics, University of British Columbia, Vancouver, Canada, August 10, 2006.

Invited Speaker, Workshop on Statistical Methods in HIV/AIDS and Its Practical Application, NIAID/NIH, Bethesda, MD, October 10, 2006.

Invited seminar speaker, Departments of Statistics and Statistical Laboratory, Iowa State University, Ames, Iowa, November 15, 2006.

Invited colloquium speaker, Department of Biostatistics, Columbia University, New York City, New York, November 30,2006.

2005

Peer-reviewed oral presentation, the 12th conference on retroviruses and opportunistic infections, Boston, Massachusetts, Feb. 22-26, 2005.

Invited speaker, Workshop on Biomarkers in HIV and Cancer Research, Mathematical Biosciences Institute, Columbus, Ohio, April 18-22, 2005.

Invited speaker, International Conference on Design of Experiments: Theory and Applications, Memphis, Tennessee, May 13-15, 2005.

Guest speaker, the Workshop on Modeling the Rapid Evolution of Infectious Diseases: Epidemiology and Treatment Strategies, the University of Western Ontario, London, Ontario, Canada, May 14-17, 2005.

Invited speaker, the 2005 WNAR/IMS Meeting, Fairbanks, Alaska, June 21-24, 2005.

Speaker at a special contributed session and chaired an invited session, the Joint Meeting of CSPS/IMS, Beijing, China, July 9-12, 2005.

Invited speaker, Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY, October 6, 2005.

Invited speaker, Department of Mathematics, University of Michigan, Ann Arbor, MI, October 11, 2005.

Colloquium Speaker, Department of Statistics, Texas A&M University, College Station, Texas, December 8, 2005.

Invited Speaker, Department of Mathematics, Tamkang University, Tamkang, Taiwan, December 27, 2005.

Invited Speaker, National Institutes of Health of Taiwan, Taiwan, December 30, 2005.

2004

Invited colloquium speaker, Department of Biostatistics, Columbia University, New York City, New York, February 26, 2004.

Invited speaker, 32nd Annual Meeting of the Statistical Society of Canada, Montreal, Canada. May 30-June 2, 2004.

Session organizer/chair and coauthor of the invited talk, ICSA 2004 Applied Statistics Symposium, International Chinese Statistical Association, San Diego, California, USA. June 6-9, 2004.

Session chair and invited speaker, International Conference on Statistics in Health Sciences, Nantes, France. June 23-25, 2004.

Session organizer and invited speaker, The Sixth ICSA International Conference, International Chinese Statistical Association, Singapore. July 21-24, 2004.

Invited speaker, Chinese Center for Disease Control and Prevention, Beijing, P.R. China. August 3, 2004.

Invited speaker, 2004 Joint Statistical Meetings, Toronto, Canada. August 8-12, 2004.

Invited speaker, the 2nd Workshop on Monte Carlo Methods, Harvard University, Cambridge, Massachusetts, USA. August 27-28, 2004.

Invited speaker, Workshop of Computational Biology of Infectious Diseases, Statistical and Applied Mathematical Sciences Institute (SAMSI), Research Triangle Park, North Carolina. Sept. 19-22, 2004.

Invited speaker, Lectureship Series, Center for Statistical Sciences, Brown University, Providence, Rhode Island. October 18, 2004.

2003

Peer-reviewed poster presentation, the 10th Conference on Retroviruses and Opportunistic Infections, Boston, Massachusetts, February 10-14, 2003.

Peer-reviewed poster presentation, the HIV Dynamics & Evolution 10th International Workshop, UCLA Conference Center, Lake Arrowhead, California, April 13-16, 2003.

Invited talk, Conference on New Directions in Experimental Design, DAE 2003, Chicago, Illinois, May 15-17, 2003.

Invited speaker, the 10th Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Los Angeles, California, June 20-21, 2003.

2002

Peer-reviewed poster presentation, 9th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, Feb. 24-28, 2002.

Invited talk, 2002 Applied Statistics Symposium, International Chinese Statistical Association, Plymouth Meeting, Pennsylvania, June 6-8, 2002.

Invited talk, International Conference on Current Advances and Trends in Nonparametric Statistics, Crete, Greece, July 15-19, 2002.

Invited talk, Los Alamos National Laboratory, Los Alamos, New Mexico, September 30, 2002.

2001

Invited talk, Department of Mathematics, University of North Carolina at Charlotte, Charlotte, North Carolina, March 29, 2001.

2000

Peer-reviewed poster presentation, the 7th Conference on Retroviruses and Opportunistic Infections, San Francisco, California, January 30-February 3, 2000.

Invited speaker, 40th Anniversary Celebration, Department of Statistics, The Florida State University, Tallahassee, Florida, April 21-22, 2000.

Invited guest speaker, 5th Beijing-Tianjin Young Statistician Meetings, Beijing, China, May 13, 2000.

Invited talks, Institute of Systems Science, Chinese Academy of Sciences, Beijing, China, May 17-18, 2000.

1999

Invited talk, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, January, 1999.

Invited talk, Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, January, 1999.

Invited talk, Department of Biostatistics, Harvard University, Boston, Massachusetts, January, 1999.

Guest speaker, Pediatric AIDS Clinical Trials Group (ACTG) Pharmacology Retreat, Minneapolis, Minnesota, March 6-7, 1999.

Invited talk, Pharmacology Committee Meetings, Adult AIDS Clinical Trials Group (ACTG) Leadership Retreat, San Diego, California, April 8-10, 1999.

Invited talk, 3rd World Multiconference on Systemics, Cybernetics and Informatics (SCI'99) and 5th International Conference on Information Systems Analysis and Synthesis (ISAS'99), Orlando, Florida, July 31-August 4, 1999.

Invited talk, Department of Mathematics and Statistics, University of Massachusetts at Amherst, Amherst, Massachusetts, November 29, 1999.

1998

Invited speaker, the 5th Annual HIV Dynamics & Evolution Conference, Santa Fe, New Mexico, April, 1998.

Invited speaker, the AIDS Clinical Trials Group (ACTG) Leadership Retreat, San Diego, California, April, 1998.

Peer-reviewed poster presentation, the 2nd International Workshop on HIV Drug Resistance & Treatment Strategies (won Young Scientist Scholarship Fund Award), Lake Maggiore, Italy, June, 1998.

Peer-reviewed oral presentation, the 12th World AIDS Conference, Geneva, Switzerland, June 28-July 3, 1998.

Invited talk, Department of Mathematics, Tamkang University, Tamkang, Taiwan,November 10, 1998.

1997

Invited to present two papers at the viral dynamic meeting in the AIDS Clinical Trials Group (ACTG) Leadership Retreat, San Diego, California, March, 1997.

Invited talk, the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, St. Petersburg, Florida, June, 1997.

Invited speaker, the 23rd AIDS Clinical Trials Group Meeting, Washington, DC, July, 1997.

Guest speaker, the Scientific Think Tank Meeting, the Women and Infants Transmission Study (WITS), NIH/NIAID, Rockville, Maryland, September, 1997.

1996

Invited talk, Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, May, 1996.

Research Grants (As Principal Investigator or Co-Principal Investigator)

  • Principal Investigator: NIH Grant R29 AI 43220, "Models and Inferential Tools for HIV-1 Dynamics in Vivo," funded (FIRST Award) by the National Institute of Allergy and Infectious Diseases/NIH, 1998-2003.
  • Principal Investigator: NIH Grant R01 AI 45356, "Modeling Cellular Kinetics in Treated HIV Patients," funded by the National Institute of Allergy and Infectious Diseases/NIH, 1999-2003.
  • Principal Investigator: NIH Grant R01 AI 52765, "Non-parametrical Modeling of Long-Term HIV/Cell Dynamics," funded by the National Institute of Allergy and Infectious Diseases/NIH, 2002-2006.
  • Principal Investigator: NIH Grant R01 AI 055290, "AIDS Clinical Trial Modeling and Simulations," funded by the National Institute of Allergy and Infectious Diseases/NIH, 2003-2008.
  • Principal Investigator & Director: NIH Grant Contract NOI-AI 50020,"Center for Biodefense Immune Modeling," Funded by NIAID/NIH, 2005-2015.
  • Co-Principal Investigator & Co-Director: NIH Grant UL1 RR024160, "The Biomedical Informatics (BI) Key Function, the University of Rochester's Clinical and Translational Science Institute," (Co-PIs: Drs. David Krusch and Dongwen Wang), funded by NIH/NCRR, 2006-2011.
  • Co-Principal Investigator: Novel Methodology CTSI grant, "Development of Objective Gating Methods for High-Dimensional Flow Cytometry Data for Translational Research," (Co-PI with Dr. Tim Mosmann), funded by the University of Rochester CTSI, 2008-2009.
  • Principal Investigator: NIH Subcontract, R21 AI078842, "Analysis of Differential Resistance Emergence Risk for Differential Treatment Applications," (PI at University of Delaware: Ryan M. Zurakowski), funded by NIAID/NIH, 2009-2011.
  • Principal Investigator: Multidisciplinary Pilot Award, University of Rochester Developmental Center for AIDS Research (D-CFAR), "Meta-Population Model of HIV/TB Co-Epidemics in a Cape Town Community," funded by NIAID/NIH, 2009-2010.
  • Principal Investigator: NIH Grant RO1 AI087135, "Estimation Methods for Nonlinear ODE Models in AIDS Research," funded by NIAID/NIH 2010-2013.
  • Principal Investigator: Novel Methodology CTSI grant, "Development of Statistical Methods and Bioinformatics Tools for Modeling Dynamic Gene Regulatory Networks for Translational Research - A Systems Biology Approach," funded by the University of Rochester CTSI, 2010-2012 .
  • Co-Principal Investigator: NIH Institutional Research Training Grant (T32), "Training in Biostatistics for HIV/AIDS," (Co-PI: Dr. Hua Liang), funded by NIAID/NIH 2010-2015.
  • Principal Investigator: Administrative Supplements (for U.S. - China Biomedical Collaborative Research on Cancer, Allergy, Immunology, and Infectious Diseases including HIV/AIDS and its Co-morbidities) to the NIH Grant RO1 AI087135, “Estimation Methods for Nonlinear ODE Models in AIDS Research,” funded by NIAID/NIH, 2011-2012.
  • Co-Principal Investigator (Contact-PI): NIH Grant NO1 AI 50020, “Center for Biodefense Immune Modeling," (Co-PI: Martin Zand, M.D./Ph.D.) funded by the National Institute of Allergy and Infectious Diseases/NIH (5-year renewal), 2010-2015
  • Principal Investigator: NIH Subcontract, R21 AI110288, “HIV 2LTR Dynamics and Cryptic Viremia,” (PI at University of Delaware: Ryan M. Zurakowski), funded with a budget of $32,340 (total cost) by NIAID/NIH, 2014-2016.
  • Principal Investigator: NIH Grant 2 R01 AI087135-05 (renewed), “Statistical Methods for ODE Models in AIDS Research,” funded with a budget of $1,718,851 (total cost) by NIAID/NIH, 5/08/2015-04/30/2020.

Research Grants (As Core Director, Co-Investigator or Statistician)

  • My Role: Senior Statistician and Section Head, NIH Grant U01 AI38855, “Adult ACTG-Statistical Analysis and Data Management Center,” (PI: Victor De Gruttola and Michael Hughes), a contract project funded by the National Institute of Allergy and Infectious Diseases/NIH, 1996–2003.
  • My Role: Senior Statistician, NIH Grant P01 AI56356, “HSV-1 Amplicon Vectors for HIV Vaccine Delivery,” (PI: Michael C. Keefer), a program project funded by the National Institute of Allergy and Infectious Diseases/NIH, 2003–2008.
  • My Role: Senior Statistician, NIH Grant RO1 HL079511, “Images of a Healthy Worksite,” (PI: Isabel Diana Fernandez), funded by NHLBI/NIH, 2004–2008.
  • My Role: Statistician, ATPM Grant, “Baby-Friendly’s Impact on Duration and Exclusivity,” (PI: Ann Marie Dozier), funded by ATPM, 2004-2005.
  • My Role: Steering Committee Member and Director of the Biomathematics, Biostatistics and Bioinformatics Core, Developmental-Center for AIDS Research (D-CFAR), (Co-PIs: Drs. Stephen Dewhurst and Michael Keefer), funded by the National Institute of Allergy and Infectious Diseases/NIH, 2008–2013.
  • My Role: Director, Biostatistics  and Data Management Core, the New York Influenza Center of Excellence (NYICE), Co-PIs: Drs. John Treanor and David Topham, funded by NIAID/NIH, 2007-2014.
  • My Role: Co-Investigator and Statistician, URMC CTSI Novel Methodology Grant, “Using Heavy Water in vivo Labeling to Measure Human Proliferation and Die-Away Kinetics- Development of the Core Facility at the University of Rochester,” (PI: Frances Eun-Hyung Lee, MD), funded by URMC CTSI, 2007-2008.
  • My Role: Co-Investigator and Senior Statistician, NIH Grant RO1 DC009395, “Hearing Impairment in HIV/AIDS,” (PI: Amneris E. Luque), funded by NIAID/NIH, 2009-2014.
  • My Role: Senior Statistician, CDC Grant 3 U48 DP001910-01S1, “The Rochester Prevention Research Center,” (PI: Tom Pearson), funded by CDC, 2009-2014.
  • My Role: Director, Biostatistics and Modeling Core, NIH Program Grant 3PO1 MH64570, “Novel Adjunctive Therapies for NeuroAIDS,” (PI: Harris A. Gelbard, M.D./Ph.D.), funded by NIH, 2010-2015.
  • My Role: Director, Biostatistics and Data Management Core, NIH Program Grant 1 PO1 AI078907, “B Cells in Health and Disease,” (PI: Ignacio Sanz, MD), funded by NIAID/NIH, 2010-2015.
  • My Role:Director, the Biostatistics, Bioinformatics and Computational Biology Core and the Steering Committee Member, Center for AIDS Research (D-CFAR), (Co-PIs: Drs. Stephen Dewhurst and Michael Keefer), funded by the National Institute of Allergy and Infectious Diseases/NIH, 2013–2018.
  • Director, Data Management and Computational Biology Core, HHSN27220201200005C, “Respiratory Pathogens Research Center (RPRC),” (PI: David Topham, Co-PI, Ann Falsey), funded by NIAID/NIH, 2011-2018.

Research Projects