Publications

Outcome Papers

Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial
Roberto Bolli, Emerson C. Perin, James T. Willerson, Phillip C. Yang, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN) J Am Coll Cardiol CardioOnc (2020) Volume 2, Issue 4, pgs 581-595.

TIME Trial - Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis
Jay H. Traverse, Timothy D. Henry, Carl J. Pepine, James T. Willerson, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN) Circ Res (2018) Volume 122, pgs. 479-488.

Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial
Emerson C. Perin, Michael P. Murphy, Keith L. March, Roberto Bolli, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN) Circulation (2017) Volume 135, pgs. 1417-1428.

One-Year Follow-up of Intracoronary Stem Cell Delivery on Left Ventricular Function Following ST-Elevation Myocardial Infarction
Jay H. Traverse, Timothy D. Henry, Carl J. Pepine, James T. Willerson, and Stephen G. Ellis. JAMA (2014) Volume 311, Issue 3, pgs. 301-302.

Effect of Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: The TIME Randomized Trial
Jay H. Traverse, Timothy D. Henry, Carl J. Pepine, James T. Willerson, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). JAMA (2012) Volume 308, Issue 22, pgs. 2380-2389.

Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Ischemic Heart Failure: The FOCUS-CCTRN Trial
Emerson C. Perin, James T. Willerson, Carl J. Pepine, Timothy D. Henry, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). JAMA (2012) Volume 307, Issue 16, pgs. 1717-1726.

Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: the LateTIME Randomized Trial
Jay H. Traverse, Timothy D. Henry, Stephen G. Ellis, Carl J. Pepine, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). JAMA (2011) Volume 306, Issue 19, pgs. 2110-2119.

Design Papers

Rationale and Design of the CONCERT-HF (Combination Of meseNchymal and c-kit+ Cardiac stEm cells as Regenerative Therapy for Heart Failure) Trial
Roberto Bolli, Joshua M. Hare, Keith L. March, Carl J. Pepine, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Circ Res (2018) Volume 122, pgs. 1703-1715.

Rationale and Design of the SENECA (StEm cell iNjECtion in cAncer survivors) Trial
Roberto Bolli, Joshua M. Hare, Timothy D. Henry, Carrie G. Lenneman, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J (2018) Volume 201, pgs. 54-62.

Rationale and Design for PACE: Patients with Intermittent Claudication Injected with ALDH Bright Cells
Emerson C. Perin, Michael Murphy, John P. Cooke, Lem Moyé, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J (2014) Volume 168, Issue 5, pgs. 667-673.

Rationale and Design for TIME: A Phase-II, Randomized, Double-Blind, Placebo-Controlled Pilot Trial Evaluating the Safety and Effect of Timing of Administration of Bone Marrow Mononuclear Cells Following Acute Myocardial Infarction
Jay H. Traverse, Timothy D. Henry, Douglas E. Vaughan, Stephen G. Ellis, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J (2009) Volume 158, Issue 3, pgs. 356-363.

A Phase-II, Randomized, Placebo-Controlled, Double-Blind Pilot Trial Evaluating the Safety and Effect of Administration of Bone Marrow Mononuclear Cells Two to Three Weeks Following Acute Myocardial Infarction: Rationale and Design for LateTIME
Jay H Traverse, Timothy D Henry, Douglas E. Vaughan, Stephen G. Ellis, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Texas Heart Institute J (2010) Volume 37, Issue 4, pgs. 412-420.

Rationale and Design for the Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells for Patients with Chronic Ischemic Heart Disease and Left Ventricular Dysfunction Trial (FOCUS)
James T. Willerson, Emerson C. Perin, Stephen G. Ellis, Carl J. Pepine, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J (2010) Volume 160, Issue 2, pgs. 215-223.

Developing Mechanistic Insights into Cardiovascular Cell Therapy - Cardiovascular Cell Therapy Research Network (CCTRN) Biorepository Core Laboratory Rationale
Claudia Zierold, Marjorie Carlson, Udo Obodo, Elizabeth Wise, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J (2011) Volume 162, Issue 6, pgs. 973-980.

Baseline Assessment and Comparison of Arterial Anatomy, Hyperemic Flow and Skeletal Muscle Perfusion in Peripheral Artery Disease: The CCTRN PACE Study
Bharath Ambale Venkatesh, Victor Nauffal, Chikara Noda, Tomoki Fujii, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J (2017) Volume 183, pgs. 24-34.

Other Papers

Expectations of Cell Therapy: An Evaluation of the Cardiovascular Cell Therapy Research Network (CCTRN) Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial
Shelly L. Sayre, Judy Bettencourt, Michelle Cohen, Rachel W. Vojvodic,  et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Clinical Researcher (2018) Volume 32, Issue 5. 

Training Clinical Research Coordinators of the Cardiovascular Cell Therapy Research Network (CCTRN) Using an Online Learning Platform
Joseph Cosico, Jennifer Chambers, Rachel Olson,  et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Clinical Researcher (2018) Volume 32, Issue 1. 

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1beta and IL-6 Related Impairment of Bone Marrow Function
Mahan Shahrivari, Elizabeth Wise, Micheline Resende, Jonathan J. Shuster, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Circ Res (2017) Volume 120, Issue 12, pgs. 1947-1957. 

Circulating Biomarkers to Identify Responders in Cardiac Cell Therapy
Jesse V. Jokerst, Nicholas Cauwenberghs, Tatiana Kouznetsova, Francois Haddad, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Sci Rep. (2017) Volume 7, Article number: 4419.

Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials
Ariadna Contreras, Aaron F. Orozco, Micheline Resende, Robert C. Schutt, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Basic Research in Cardiology. (2017) Volume 112, Issue 1, pgs 1-10.

Identification of Bone Marrow Cell Subpopulations Associated with Improved Functional Outcomes in Patients with Chronic Left Ventricular Dysfunction: An Embedded Cohort Evaluation of the FOCUS-CCTRN Trial
Doris A. Taylor, Emerson C. Perin, James T. Willerson, Claudia Zierold, et al for the Cardiovascular Cell Therapy Research Network (CCTRN). Cell Transplantation (2016) Volume 25, pgs.1675-1687.

Bone Marrow Cell Characteristics Associated with Patient Profile and Cardiac Performance Outcomes in the LateTIME-CCTRN Trial 
Aruni Bhatnagar, Roberto Bolli, Brian H. Johnstone, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Am Heart J. (2016) Volume 179, pgs.142-150.

Unipolar Voltage Assessed by Endomyocardial Mapping Predicts Change in Ejection Fraction among Patients with Ischemic Cardiomyopathy 
Ki Park, Dejian Lai, Eileen M. Handberg, Lem Moyé, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Tex Heart Inst J (2016) Volume 43, Issue 4, pgs. 291-6.

Concise Review: Review and Perspective of Cell Dosage and Routes of Administration from Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease
Samuel Golpanian, Ivonne H. Schulman, Ray F. Ebert, Alan W. Heldman, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Stem Cells Trans Med (2016) Volume 5, Issue 2, pgs. 86-191.

Clinical Research Skills Development Program in Cell-Based Regenerative Medicine
Ivonne Hernandez Schulman, Viky Suncion, Vasileios Karantalis, Wayne Balkan, and Joshua M. Hare for the Cardiovascular Cell Therapy Research Network (CCTRN). Stem Cells Trans Med (2015) Volume 4, pgs. 118-122.

A Training Program in Cardiovascular Cell-based Therapy: From the NHLBI Cardiovascular Cell Therapy Research Network
John W. Petersen, David E. Winchester, Ki Park, Anita D. Szady, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Regen Med (2014)  Volume 9, Issue 6, pgs.793-7.

Bone Marrow Characteristics Associated with Changes in Infarct Size After STEMI: A Biorepository Evaluation from the CCTRN TIME Trial
Robert C. Schutt, Barry H. Trachtenberg, John P. Cooke, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Circ Res (2015) Volume 116, Issue 1, pgs. 99-107.

A Detailed Analysis of Bone Marrow from Patients with Ischemic Heart Disease and Left Ventricular Dysfunction: BM CD34, CD11b, and Clonogenic Capacity as Biomarkers for Clinical Outcomes
Christopher R. Cogle, Elizabeth Wise, Amy M. Meacham, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Circ Res (2014) Volume 115, Issue 10, pgs. 867-874.

DAMASCENE and Meta-Ecological Research: A Bridge Too Far
Moyé, Lem. Circ Res (2014) Volume 115, Issue 5, pgs. 484-487.

Clinical Monitoring in a Federally Funded Environment: Evolution and Opportunities in the Cardiovascular Cell Therapy Research Network
Sibi R. Mathew, Kristen D. Lucas, Shelly L. Sayre, Judy Bettencourt et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). The Monitor (2014) pgs. 31-36.

Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis
Ronak Delewi, Alexander Hirsch, Jan G. Tijssen, et al. Eur Heart J (2014) Volume 35, Issue 15, pgs. 989-998.

Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infarction: A Perspective from the CCTRN
Robert D. Simari, Carl J. Pepine, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Circ Res (2014) Volume 114, Issue 10, pgs. 1564-1568.

Mesenchymal Precursor Cells as Adjunctive Therapy in Recipients of Contemporary Left Ventricular Assist Devices
Deborah D. Ascheim, Annetine C. Gelijns, Daniel Goldstein, et al. Circ (2014) Volume 129, Issue 22, pgs. 2287-2296.

Recruiting for Acute Myocardial Infarction Cell Therapy Trials: Challenges and Best Practices
Rachel E. Olson, Rachel W. Vojvodic, Judy Bettencourt, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Clinical Researcher (2014) pgs. 71-77.

Phase II Clinical Research Design in Cardiology Learning the Right Lessons Too Well: Observations and Recommendations from the Cardiovascular Cell Therapy Research Network (CCTRN)
Joshua M. Hare, Roberto Bolli, John P. Cooke, David J. Gordon et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Circ (2013) Volume 127, Issue 15, pgs. 1630-1635.

A Critical Analysis of Clinical Outcomes Reported in Stem Cell Trials for Acute Myocardial Infarction: Some Thoughts for Design of Future Trials
Anita D. Szady, Carl J. Pepine, Shreela V. Sharma, Christopher R. Cogle, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Curr Atherosclerosis Rep (2013) Volume 15, Issue 8, pgs. 341-013-0341-9.

Implementation of Cardiovascular Cell Therapy Network trials – challenges, innovation and lessons learned from experience in the CCTRN
Ki E. Park, Lemuel A. Moyé, Timothy D. Henry, Emerson C. Perin, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Expert Rev in Cardiovasc Ther (2013) Volume 11, Issue 11, pgs. 1495-1502.

Factors affecting the Turnaround Time for Manufacturing, Testing and Release of Cellular Therapy Products prepared at Multiple Sites in support of Multicenter Cardiovascular Regenerative Medicine Protocols – a Cardiovascular Cell Therapy Research Network (CCTRN) Study
Sara J. Richman, Adrian P. Gee, David H. McKenna, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Transfusion (2012) Volume 52, Issue 10, pgs. 2225-2233.

Cell tracking and the development of cell-based therapies: a view from the Cardiovascular Cell Therapy Research Network (CCTRN)
Martin Rodriguez-Porcel, Marvin W. Kronenberg, Timothy D. Henry, Jay H. Traverse, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). JACC Cardiovasc Imaging (2012) Volume 5, Issue 5, pgs. 559-565.

Quantification of Myocardial Segmental Function in Acute and Chronic Ischemic Heart Disease and Implications for Cardiovascular Cell Therapy Trials: A Review from the NHLBI-Cardiovascular Cell Therapy Research Network
John Petersen, John R. Forder, James D. Thomas, Lemuel A. Moyé, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). JACC Cardiovasc Imaging (2011) Volume 4, Issue 6, pgs. 671-679.

Oversight and Management of a Cell Therapy Clinical Trial Network: Experience and Lessons Learned
Lemuel A. Moyé, Shelly L. Sayre, Lynette Westbrook, Beth C. Jorgenson, et al. for the Cardiovascular Cell Therapy Research Network (CCTRN). Cont Clin Trials (2011) Volume 32, Issue 5, pgs. 614-619.

Cell Therapy and Satellite Centers: The Cardiovascular Cell Therapy Research Network Experience
Lemuel A. Moyé, Timothy D. Henry, Ken W. Baran, Judy L. Bettencourt, et al for the Cardiovascular Cell Therapy Research Network (CCTRN). Cont Clin Trials (2011) Volume 32, Issue 6, pgs. 841-847.

Development of a Network to Test Strategies in Cardiovascular Cell Delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN)
Robert D. Simari, Lemuel A. Moyé, Sonia I. Skarlatos, Stephen G. Ellis, et al. Journal of Cardiovascular Translational Research (2010) Volume 3, Issue 1, pgs. 30-36.

Multicenter Cell Processing for Cardiovascular Regenerative Medicine Applications - The Cardiovascular Cell Therapy Research Network (CCTRN) Experience
Adrian P. Gee, Sara Richman, April Durett, David McKenna, et al. Cytotherapy (2010): Volume 12, Issue 5, pgs. 684-691.