Virtual Seminar: Dr. Thomas Mathew on Reference intervals and regions in laboratory medicine
When & Where
September 26, 2023
12:00 PM - 1:00 PM
Contact
- Scott Dyson
- [email protected]
Event Description
When: 12pm, Sep. 26
Where: WebEx (See event website link). Password: X89MnZE7bAA
Presenter: Thomas Mathew, Ph.D., Department of Mathematics & Statistics, University of Maryland Baltimore County (UMBC)
Title: Reference intervals and regions in laboratory medicine
Abstract:
Reference intervals are data-based intervals that are meant to capture a pre-specified large proportion of the population values of a clinical marker or analyte in a healthy population. They can be one-sided or two-sided, and they are widely used in the interpretation of results of biochemical and physiological tests of patients. A population reference range is typically expected to include 95% of the population distribution, and reference limits are often taken to be the 2.5th and 97.5th percentiles of the distribution, which is especially meaningful if normality is appropriate. Usually the reference range is constructed based on a random sample and simply estimating the percentiles is clearly not satisfactory. This calls for the use of appropriate criteria for estimating the reference range from a random sample. When there are multiple biochemical analytes measured from each subject, a multivariate reference region is needed. Traditionally, under multivariate normality, reference regions have been constructed as ellipsoidal regions. This approach suffers from a major drawback: it cannot detect component-wise extreme observations. Thus rectangular reference regions need to be constructed based on appropriate criteria. The talk will review univariate reference intervals and multivariate reference regions, and the criteria that can be used in their construction. Both parametric and non-parametric scenarios will be addressed, and laboratory medicine examples will be used for illustration.
Event Site Link
https://uthealth.webex.com/uthealth/j.php?MTID=m53b7a21ab1b4ed251b2ea983fa221c19
Additional Information
When: 12pm, Sep. 26
Where: WebEx (See event website link). Password: X89MnZE7bAA
Presenter: Thomas Mathew, Ph.D., Department of Mathematics & Statistics, University of Maryland Baltimore County (UMBC)
Title: Reference intervals and regions in laboratory medicine
Abstract:
Reference intervals are data-based intervals that are meant to capture a pre-specified large proportion of the population values of a clinical marker or analyte in a healthy population. They can be one-sided or two-sided, and they are widely used in the interpretation of results of biochemical and physiological tests of patients. A population reference range is typically expected to include 95% of the population distribution, and reference limits are often taken to be the 2.5th and 97.5th percentiles of the distribution, which is especially meaningful if normality is appropriate. Usually the reference range is constructed based on a random sample and simply estimating the percentiles is clearly not satisfactory. This calls for the use of appropriate criteria for estimating the reference range from a random sample. When there are multiple biochemical analytes measured from each subject, a multivariate reference region is needed. Traditionally, under multivariate normality, reference regions have been constructed as ellipsoidal regions. This approach suffers from a major drawback: it cannot detect component-wise extreme observations. Thus rectangular reference regions need to be constructed based on appropriate criteria. The talk will review univariate reference intervals and multivariate reference regions, and the criteria that can be used in their construction. Both parametric and non-parametric scenarios will be addressed, and laboratory medicine examples will be used for illustration.
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