ACTG 315 Long-Term Viral Dynamics for Semiparametric Nonlinear Mixed-Effects Models


1. The data were produced from AIDS Clinical Trials Group, ACTG 315 study, which is sponsored by NIAID/NIH. If you have any questions regarding the data, you may contact Dr. Hulin Wu by email: [email protected].

2. The detailed biomedical findings from this study and more detailed description of the study design can be found from the primary and secondary publications of this study, Lederman et al (1998) and Connick et al. (2000) (see below for these references).

3. This data set was used in the paper by Wu and Zhang (2002, Statistics in Medicine) in which more details about the data can be found. A semiparametric Nonlinear Mixed-Effects (NLME) Models was proposed to fit to this data set in this paper.

4. Early viral dynamics of this study was modeled by

Some further viral dynamic analyses for this study (including other long-term viral dynamics and covariates analyses) can be found in other pages of our website.

5. Forty-eight evaluable HIV-1 infected patients were treated with potent antiviral therapy consisting of ritonavir, 3TC and AZT. The viral load were monitored at treatment days -35,-7, 0,2,7,10,14,28,56, 84, 168 and 336. The viral load data below detection limit were imputed as 50.

6. Please cite the following references if appropriate when you use the data in your paper:

1) Connick E, Lederman MM, Kotzin BL, et al. (2000), "Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response," Journal of Infectious Diseases, 181:358-63.

2) Lederman MM, Connick E, Landay A, et al. (1998), "Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine and ritonavir: results of AIDS Clinical Trials Group Protocol 315," Journal of Infectious Diseases, 178: 70-79.

3) Wu, H. and Ding, A. (1999), "Population HIV-1 Dynamics in Vivo: Applicable Models and Inferential Tools for Virological Data from AIDS Clinical Trials," Biometrics, 55, 410-418.

4) Wu, H., Kuritzkes, D.R., and McClernon, D.R. et al. (1999), "Characterization of Viral Dynamics in Human Immunodeficiency Virus Type 1-Infected Patients Treated with Combination Antiretroviral Therapy: Relationships to Host Factors, Cellular Restoration and Virological Endpoints," Journal of Infectious Diseases, 179(4):799-807.

5) Wu, H. and Zhang, J. T. (2002) "The study of long-term HIV dynamics using semiparametric nonlinear mixed-effects models. Statistics in Medicine, 21, 3655-3675.